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  • Saturday 19 September
    08:00-10:00

  • IC 31
  • A Look to the Future: 3D & “Heads Up” Wide Angle MIVS Retina Surgery in 2015

    J. Nikolapoulos GREECE T. Aaberg USA

    Abstract    Schedule



  • Chairperson: A. Nikolakopoulos GREECE


    Moderators: C. Riemann USA, T. Aaberg USA, A. Nikolakopoulos GREECE,
    V. Ferrara ITALY


    Cost: €25

    • 08.00
    • T. Aaberg USA


    • 08.10
    • C. Riemann USA


    • 08.20
    • S. Rizzo ITALY


    • 08.30
    • Y. Oshima JAPAN


    • 08.40
    • F. Balta ROMANIA


    • 08.50
    • M. Mura THE NETHERLANDS


    • 09.00
    • S. Gotzaridis GREECE


    • 09.10
    • K. Kadonosono JAPAN


    • 09.20
    • F. Boscia ITALY


    • 09.30
    • C. Forlini ITALY


    • 09.40
    • C. Claes BELGIUM


    • 09.50
    • A. Nikolakopoulos GREECE



    • 10.00

    • End of course


  • Saturday 19 September
    08:00-09:30

  • IC 32
  • wetlab prerequisite
    A State-of-the-Art in Intravitreal Therapy:

    U. Schmidt-Erfurth AUSTRIA

    Abstract    Schedule



  • Organiser: U. Schmidt-Erfurth AUSTRIA


    Cost: €25

    • 08.00
    • A. Loewenstein ISRAEL

      Anti-VEGF treatment in neovascular AMD: Where are we in 2015?


    • 08.15
    • S. Sadda UNITED STATES

      Geographic atrophy and intravitreal therapy: Rationale and perspectives



    • 08.30
    • U. Schmidt-Erfurth AUSTRIA

      DME and DR: Update on anti-angiogenic therapy from recent trials



    • 08.45
    • J. Mones SPAIN

      Vein occlusion:Substances, indications, follow-up



    • 09.00
    • M. Georgopoulos AUSTRIA

      Pharmacologic vitrolysis versus vitrectomy



    • 09.15
    • A. Grzybowski POLAND

      Antibiotics in intravitreal injections: Do not harm




    • 09.30

    • End of course


  • 0

  • Saturday 19 September
    11:00-12:30

  • IC 33
  • Managing Diabetic Macular Edema: Pearls and Pitfalls

    E. Midena ITALY A. Joussen GERMANY

    Abstract    Schedule

  • Course

    Organiser: E. Midena Italy, A. Joussen Germany


    Cost: €25

    • 11.00
    • A. Joussen Germany

      DME is a multifactorial disease: from bench to bedside for a tailored treatment



    • 11.15
    • T. Peto UK

      The screening of DME around: present an future perspectives



    • 11.30
    • S. Vujosevic Italy

      Multimodal retinal imaging in DME: is it essential?



    • 11.45
    • E. Midena Italy

      DME treatment: from RCT studies to daily practice



    • 12.00
    • S. Sivaprasad UK

      Intriguing DME cases


    • 12.15

    • Discussion

    • 12.30

    • End of course


  • Managing Diabetic Macular Edema: Pearls and Pitfalls

    Targeted audience and level.
    Retina specialists /comprehensive ophthalmologists
    Medium and Advanced Level

    Abstract:

    Background: Diabetic macular edema (DME) is the leading cause of legal blindness in diabetic patients, occurring at any stage of diabetic retinopathy, although more likely as the disease progresses. DME can be asymptomatic until severe and irreversible visual loss is present. Therefore its early diagnosis (with proper imaging modalities) is fundamental to obtain a better identification of different DME phenotypes, which need a tailored treatment in order to obtain the best functional result.
    Precise outline: This course will cover, clinically relevant aspects of DME, from main biochemical mechanisms involved in its multifactorial pathogenesis to the most appropriate clinical assessment and choice of treatment. Moreover, screening challenges and margins of improvement delivered around the world, will be also discussed.
    Course Objectives: At the conclusion of this course the attendees will be able to critically manage and treat patients with DME.
    Course Outline:

    Diabetic macular edema (DME) is the leading cause of impaired visual acuity in patients affected by diabetes mellitus (DM). The pathophysiology of DME involves many interconnected pathways with specific contributions, thus determining different DME phenotypes. Diabetic retinopathy (DR), together with DME, is not only a vascular, but also a neuroinflammatory disease. Slit-lamp biomicroscopy, fluorescein angiography (FA), optical coherence tomography (OCT), fundus autofluorescence (FAF), microperimetry (MP) and retromode scanning laser ophthalmoscope (RM-SLO), have all been used for diagnosis and follow-up of DME and also for better identifying different DME characteristics and phenotypes.
    In particular the use of non-invasive imaging modalities has significantly increased lately. Spectral Domain (SD-OCT) has been recently used for the evaluation: of intraretinal hyperreflective spots (foci/dots), choroidal thickness, reflectivity of intra/subretinal fluid and outer retina integrity. Even though laser photocoagulation has still an important role in the treatment of DME, intravitreal treatments, in particular anti-vascular endothelial growth factor (anti-VEGF) drugs and steroids, have been established as the first-line treatment in center-involving DME. Knowledge of ocular and systemic safety of these drugs, is fundamental in choosing the right treatment for each patient. Moreover, the panelists will try to give an algorithm for treatment, and especially how to identify responders vs non-rsponders as well as suggestions on what to do in non-responder DME patients.

    Suggested readings:
    1. Ehrlich R, Harris A, Ciulla TA, Kheradiya N, Winston DM, Wirostko B. Diabetic macular oedema: Physical, physiological and molecular factors contribute to this pathological process. Acta Ophthalmol. 2010;88(3):279-291
    2. Vujosevic S, Bini S, Midena G, Berton M, Pilotto E, Midena E. Hyperreflective intraretinal spots in diabetics without and with nonproliferative diabetic retinopathy: An in vivo study using spectral domain OCT. J Diabetes Res. 2013;2013:491835.
    3. Vujosevic S, Martini F, Longhin E, Convento E, Cavarzeran F, Midena E.
    Subthreshold micropulse yellow laser versus subthreshold micropulse infrared laser in center-involving diabetic macular edema: Morphologic and Functional Safety. Retina. 2015 Feb 24. [Epub ahead of print]
    4. Arevalo JF. Diabetic macular edema: Changing treatment paradigms. Curr Opin Ophthalmol. 2014;25(6):502-507.
    5. The Diabetic Retinopathy Clinical Research Network. Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema. N Engl J Med. 2015 Feb 18.

  • IC 34
  • wetlab prerequisite
    Optimising Injection Clinics

    M. Zinkernagel SWITZERLAND

    Abstract    Schedule

  • Course

    Organiser: M. Zinkernagel SWITZERLAND


    Cost: €25

    • 11.00
    • S. Wolf SWITZERLAND

      TITLE TBC



    • 11.20
    • G. Turner UK

      TITLE TBC



    • 11.40
    • P. Lanzetta ITALY

      TITLE TBC



    • 12.00
    • N. Feltgen GERMANY

      TITLE TBC





    • 12.20

    • Discussion

    • 12.30

    • End of course


  • Title:: Optimising Injection Clinics



    Course Director: Martin Zinkernagel, MD, PhD

    Targeted audience and level
    Retina specialists: Intermediate to advanced Level

    Background: Service providers specializing in intravitreal treatment of macular diseases dif-fer in their structure, size, and patient population. In addition differing healthcare systems with varying reimbursment schemes lead to a myriad of different approaches to organize in-jection clinics.
    Precise outline: This course will provide retina specialists with a comprehensive overview of clinical practices and organization of intravitreal injection clinics. The aim is to bring together retina specialists from different countries and clinical settings to report on the difficulties and advantages of their system they are confronted with during injection clinics.
    Objectives: The following outcomes will be discussed in detail:
    - Administration of injection clinics; different countries different models
    - Management of patient flow with different treatment regimens
    - Choice of intravitreal agent to optimize injection clinics
    - Advantages and disadvantages of separating patients under treatment with intravitreal agents from regular outpatients
    - The role of non-consultant staff (nurse practitioners and optometrists) to maintain monthly follow-up of patients
    - The role of medical records to monitor outcomes and the advantages or disadvantages of electronical devices to optimize injection clinics


    Outline: Given the increase of patient numbers receiving intravitreal injections for various macular diseases, pressures on clinical capacity in injection clinics are likely to increase in the next decade. Usually the number of follow up appointments is the main bottle neck during in-jections clinics. Compromises in follow up appointment intervals may have negative effects on long term maintenance of visual acuity gain as close monitoring of the majority of patients is necessary. Whereas the indication for intravitreal treatment are fairly uniform throughout the world, differing healthcare systems, reimbursement schemes and staff resources have a profound impact on how injection clinics are run. The aim of this course is to teach fellow retinologists about the disadvantages and advantages of individual injection clinic systems. At the end of each presentation the audience will have the opportunity to discuss specific points.

    Special consideration will be given to clinical premises and spatial organisation of injection clinics and injection procedures. Here the advantages and disadvantages of one-stop versus a two-stop model and the challenges of organizing a rapid access clinic for intravitreal injections will be taught to the attendees. Furthermore issues considering staffing such as the role of non-consultant staff in administrating injection clinics but also in the (re-)treatment decision making process, preparation of patient and injection process itself will be discussed and disadvantages and advantages of each system will be debated.
    Furthermore, equipment consideration such as availability of several OCTs or fluorescein an-giographs will be discussed as well as which follow up examination should be done in what intervals during injection clinic follow ups, such as visual acuity/OCT/IOP measure-ments/fluorescein angiography. Advantages or disadvantages of separation of different macu-lar diseases (AMD, RVO, DME) in regards to follow up examination will be discussed with the attendees. In addition, the advantages and disadvantages of using different visual acuity readouts such as ETDRS or snellen will be discussed.
    The role of patient education in optimizing follow up compliance and work flow during injec-tion clinics will be shown. The influence of different treatment regimens on clinic capacity will be discussed. Here, special consideration will be given to fixed, PRN or treat and extend regimens with detailed discussion about the benefits of these regimens in regards to organiz-ing injection clinics, patient compliance and optimizing Cost: s.
    Taken together, at the conclusion of this course the attendee will have gained a insight into how injection clinics can be organized and optimized.

    Selected articles:
    • Action on AMD. Optimising patient management: act now to ensure current and con-tinual delivery of best possible patient care. Eye (Lond). 2012 February; 26(Suppl 1): S2–S21.
    • Public health impact of neovascular age-related macular degeneration treatments ex-trapolated from visual acuity. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):96-103.
    • Quality of life in patients with age-related macular degeneration: impact of the condi-tion and benefits of treatment. Surv Ophthalmol. 2005 May-Jun;50(3):263-73.
    • Seven-Year Outcomes in Ranibizumab-Treated Patients in ANCHOR, MARINA, and HORIZON: A Multicenter Cohort Study (SEVEN-UP). Ophthalmology. 2013 Nov;120(11):2292-9.

  • Saturday 19 September
    14:30-16:00

  • IC 35
  • wetlab prerequisite
    Advances in Diabetic Retinopathy Screening

    E. Stefansson ICELAND

    Abstract    Schedule

  • Course Organisers: E. Stefánsson ICELAND, P. Scanlon UK


    Cost: €25

    • 14.30
    • T. Bek DENMARK

      Advances in diabetic retinopathy screening. Factors of importance for prolonging and individualizing the screening interval.
      toke.bek@mail.tele.dk



    • 14.45
    • E. Stefánsson ICELAND

      Risk assessment in diabetic eye screening
      einarste@landspitali.is



    • 15.00
    • T. Peto UK

      What do new images modalities add to diabetic retinopathy screening?
      Tunde.Peto@moorfields.nhs.uk

    •    

    • 15.15
    • P. Silva UNITED STATES

      Improving Outcomes in Teleophthalmology Programs for Diabetic Retinopathy
      PaoloAntonio.Silva@joslin.harvard.edu



    • 15.30
    • P. Scanlon UK

      The place of OCT in the English Diabetic Retinopathy Screening model
    •  
    • 15.45

    • Discussion

    • 16.00

    • End of course

  • 0

  • IC 36
  • wetlab prerequisite
    Autologous Choroidal Transplantation in AMD: Toward the RPE-Transplantation Era

    A. Polito ITALY

    Abstract    Schedule

  • Course Organisers: A. Polito ITALY


    Cost: €25

    • 14.35
    • A. Polito ITALY

      Is there an indication for surgery in exudative AMD?



    • 14.46
    • G. Pertile ITALY

      Surgical technique



    • 14.57
    • M. Cereda ITALY

      The new life of a choroidal graft: angiographic and tomographic characteristics



    • 15.08
    • E. Maggio ITALY

      Anatomic and functional outcome



    • 15.19
    • M. Mete ITALY

      RPE tears after the anti-VEGF injection: factors to take into consideration before planning the next step



    • 15.30
    • G. Pertile ITALY

      Toward the RPE-transplantation era: lessons learned from AMD’s surgery



    • 15.41

    • Discussion

    • 16.00

    • End of course


  • Title:: Autologous choroidal transplantation in AMD: toward the RPE-transplantation era


    Abstract: The Submacular Surgery Trials (SST) study demonstrated that sole removal of choroidal neovascularization (CNV) and/or blood did not significantly improve or stabilize the visual function. The damage of submacular retinal pigment epithelium (RPE) during surgery was considered to play a key role in the lack of visual improvement.
    From then on, different techniques have been studied to replace the diseased RPE, ranging from transplantation of stem cells derived RPE cells to full thickness choroidal grafts.
    Transplantation of an autologous RPE-choroid graft as described by Peyman et al and van Meurs et al, is a surgery in which healthy RPE and choroid are harvested from the midperiphery and inserted under the macula through a parafoveal retinotomy after CNV removal. Postoperative fixation and retinal sensitivity in the area of the patch have been demonstrated. In certain patients an RPE-choroid graft is able to improve visual function and improvement can be maintained in the long term. Overall long-term results, however, are rather modest with a relatively high risk of proliferative vitreoretinopathy (PVR) of 10%.
    In a variation of the surgery described by van Meurs et al, a large peripheral retinotomy at the ora serrata can be performed. Using this technique, the surgeon has a better accessibility of the subretinal space and there is less manipulation of the parafoveal retina and the graft. For these reasons, his technique has the potential to improve the outcome.
    One of the most frequent observed complications is the development of atrophic changes of the transplanted RPE. The study of the evolution of the disease can shed some light on the pathogenesis of the atrophy in AMD and anticipate what we can expect, for example, after stem cells derived RPE transplantation.

  • IC 37
  • wetlab prerequisite
    Intraocular Biopsies Could Be The Key In Complicated Intraocular Inflammatory Diagnosis

    J.C   Pastor SPAIN

    Abstract    Schedule



  • Course Leader:
    J. C. Pastor SPAIN


    Cost: €25

    • 14.30
    • J. C. Pastor SPAIN

      Indications and techniques for intraocular biopsies



    • 14.48
    • J. C. López SPAIN

      Samples management. Samples processing. Molecular Biology techniques



    • 15.06
    • A. Sala SPAIN,
      S. Pastor-Idoate SPAIN,
      E. Carreno UK

      Cases presentation and discussion.



    • 15.24
    • J. C. Pastor SPAIN

      Final remarks


    • 15.42

    • Discussion

    • 16.00

    • End of course



  • 0

  • Saturday 19 September
    16:30-18:00

  • IC 38
  • wetlab prerequisite
    Fluorescein, ICG and OCT-Angiography in Macular Diseases – Interpretation & Comparison With Other Imaging Modalities

    D. Pauleikhoff GERMANY G. Staurenghi ITALY

    Abstract    Schedule

  • Course organisers: D. Pauleikhoff COUNTRY & G. Staurenghi COUNTRY


    Cost: €25

    • 16.30
    • D. Pauleikhoff Germany

      The role of fluorescein, ICG and OCT-angiography in macular diseases - A statement towards multimodal imaging



    • 16.45
    • S. Wolf Switzerland

      Imaging tools for angiography – pros and cons



    • 17.00
    • G. Staurenghi Italy

      OCT-angiography – a new diagnostic tool



    • 17.15
    • F. Sallo UK

      Correlation of Angiography, autofluorescence, en-face OCT analysis - An example: Multmodal imaging in MacTel type 2



    • 17.30
    • A. Tufail, UK

      Angiographic assessment vs. OCT during anti-VEGF-therapy



    • 17.45
    • P. Chabel Issa Germany

      Imaging macular dystrophies – novel approaches and the value of angiography



    • 18.00

    • End of course


  • Title:: Fluorescein, ICG and OCT-angiography in macular diseases – interpretation and comparison with other imaging modalities



    Course Leader:
    D. Pauleikhoff, G. Staurenghi

    Audience Level: Retina specialists/Comprehensive ophthalmologists/ Beginner / Intermediate / Advanced

    Format Options:
    Didactic presentations with scheduled questions and answers managed by the course director

    Abstract and outline


    Course Description: The course will present the role of fluorescein and ICG but new also OCT - angiography as diagnostic tools in different macular diseases. The concept is to demonstrate its general potential in respect to and combination with other diagnostic tools (p.e. SD-OCT, autofluorescence) and to describe specific diagnostic strategies including these diagnostic tools in defined macular dieseases (AMD, MacTel type 2, inherited macular degeneration)

    Course Objectives:
    To demonstrate the general potential of Fluorescein, ICG and OCT-angiography and to describe specific diagnostic strategies including these diagnostic tools in defined macular dieseases.
    An overview about Fluorescein, ICG and OCT-angiography and its place in the multimodal diagnostic sttategies of macular dieseases

    Conclusion:
    Participants will have a better understanding of the role of Fluorescein, ICG and OCT-angiography in the multimodal diagnostic sttategies of macular dieseases






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