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Spectral domain optical coherence tomography in pediatric patients with sickle cell disease

Session Details

Session Title: Imaging IV

Session Date/Time: Sunday 20/09/2015 | 11:00-13:00

Paper Time: 12:28

Venue: Thalie.

First Author: : S.Roemer SWITZERLAND

Co Author(s): :    A. Dirana   P. Kaeser   L. Marchionno   S. Ferreira   C. Bergin   A. Ambresin

Abstract Details

PURPOSE:The aim of our study was to evaluate the macular anatomy on optical coherence tomography (OCT) in pediatric patients with Sickle cell disease (SCD)


Sickle cell disease is frequently associated with retinal manifestations. Recent studies have reported on OCT alterations in adult SCD populations.


Retrospective study of pediatric patients with SCD followed in the medical retina unit of Jules-Gonin Eye Hospital .The study group was compared to a control group matched for age, sex and ethnicity. Retinal thinning, macular splaying (foveal diameter), foveal depth and subfoveal choroidal thickness were measured using OCT (Heidelberg Engineering, Germany).


22 eyes were compared to 13 control eyes. Macular splaying was significantly lower in eyes of patients with SCD (1170±201) compared to control eyes (1401±225) (p=0.005). 36% of the SCD eyes showed retinal thinning in the temporal area. There was no difference in choroidal thickness.


Our study showed a significant decrease in macular splaying in the SCD pediatric patients and presence of focal thinning. Both reflects inner retina alterations suggesting early retinal blood flow alterations. Choroidal thickness was comparable in both groups.

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