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Segmentation errors in optical coherence tomography imaging for patients with a history of retinopathy of prematurity

Session Details

Session Title: Imaging IV

Session Date/Time: Sunday 20/09/2015 | 11:00-13:00

Paper Time: 12:12

Venue: Thalie.

First Author: : W.Wu TAIWAN

Co Author(s): :    Y. Chen              

Abstract Details

PURPOSE:To evaluate the frequency of artifacts by using spectral domain optical coherence tomography (SD-OCT) (MM5 protocol of RTVue-100; Optovue, Inc., Fremont, CA) in retinopathy of prematurity (ROP) patients of school age.


An institutional referral center.


This was designed as a prospective case-controlled study. Patients were grouped as those who had previous treatment for ROP (group 1); those who had no treatment-requiring ROP (group 2); those who were born prematurely without ROP (group 3); and those who were born full term (group 4). Demographic data, results of ophthalmic examination, segmental errors by SD-OCT, and the integrity of the photoreceptor microstructures in the foveal region were investigated and correlated with the segmentation errors found in these patients.


Images were collected from 133 eyes. The mean age at assessment was 9.5 years (range 4-16). The mean signal strength index was 68.5 (range 41.2–86.5). Artifacts were observed ranging from 0.6% to 50.0% among different groups of patients. All types of errors, including misidentification of the inner retina, misidentification of the outer retina, out of register artifacts, off-center scans, and degraded scan image, occurred more frequently in group 1 patients than in group 4 patients (all P < .05). The error type of “out of register” and “degraded artifact” occurred more frequently in group 1 patients (all P < .05). The external limiting membrane and the cone outer segment tips line were least identified in group 1 patients (65.2% and 47.8%, P = .002 and P < .001) and these findings could possibly be associated with the higher segmentation errors in group 1 patients.


Segmentation errors of SD-OCT imaging can occur in patients with or without ROP and these errors happened more often in ROP patients with prior treatments. Clinicians need to take into account for this when using OCT.  

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