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Reproducibility and repeatability of foveal avascular zone area measurements in healthy young subjects by means of optical coherence tomography angiography

Session Details

Session Title: Imaging IV

Session Date/Time: Sunday 20/09/2015 | 11:00-13:00

Paper Time: 11:48

Venue: Thalie.

First Author: : L.Di Antonio ITALY

Co Author(s): :    L. Toto   P. Carpineto   A. Mastropasqua   R. Aloia   M. Papa   L. Mastropasqua

Abstract Details

PURPOSE:To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements by means of optical coherence tomography angiography (OCT-A) in healthy subjects.

Setting:

Ophthalmology Clinic, High-Tech National Center in Ophthalmology, Department of Medicine and Aging Sciences, University “G. d’Annunzio” Chieti-Pescara, Italy

Methods:

60 healthy volunteers (60 eyes) were subjected to FAZ area measurements by means of high speed and high resolution spectral-domain optical coherence tomography (SD-OCT) XR Avanti ® (Optovue, Inc, Fremont CA, USA) with split-spectrum amplitude decorrelation angiography (SSADA) algorithm by two experienced examiners in two different sessions. The repeatability of measurements was assessed by the coefficient of repeatability (CR), the intraclass correlation coefficient (ICC) and the within subjects coefficient of variation (CVw). Inter- and intraobserver reproducibilities were tested and analyzed by means of the concordance correlation coefficient (CCC).

Results:

Mean age (±SD) was 28.9 (±7.6) years. Overall FAZ areas measured by the first and second observer were 0.251±0.096 and 0.252±0.096 mm2, respectively. Within subjects coefficient of variations (and 95% CI) were 1.83% (1.51-2.20) and 1.86% (1.33-2.43) for the first and the second observer, respectively. The CRs average measurements of FAZ area were 0.015 and 0.013 mm2 for the first and the second observer, respectively. The ICC values (95% CI) were 0.997 (0.995-0.998) and 0.998 (0.996-0.999) for the first and the second observer, respectively. Inter- and intraobserver CCCs ranged from 0.994 (95% CI: 0.990–0.977) to 0.999 (95% CI: 0.997–0.999) and from 0.997 (95% CI: 0.995–0.998) to 0.996 (95% CI: 0.994–0.998), respectively.

Conclusions:

FAZ area measurements by means of OCT-A showed both high reproducibility and repeatability in healthy eyes. OCT-A is a non invasive diagnostic method and its reliability makes it an interesting potential tool for disease detection and follow-up in retinal pathologies involving foveal microcirculation.

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