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Correlation between retinal nerve fiber layer and ganglion cell complex in primary open angle glaucoma

Session Details

Session Title: Imaging IV

Session Date/Time: Sunday 20/09/2015 | 11:00-13:00

Paper Time: 11:16

Venue: Thalie.

First Author: : H.Elsaied EGYPT

Co Author(s): :    E. Afef   T. Macky   S. Esmat        

Abstract Details

PURPOSE:To investigate the correlation between optic nerve head retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) layer changes in primary open angle glaucoma (POAG) using spectral domain optical coherence tomography(OCT).

Setting:

kasr Alaini medical school

Methods:

The study is a cross sectional observationalclinical trial in which patients diagnosed with POAG were included. Patients with history of any ocular diseases or trauma were excluded. All patients were subjected to full ophthalmic examinations and SD-OCT evaluation and analysis (correlation) of RNFL parameters and GCC parameters.

Results:

Thirty eight eyes of 38 patients with POAG were included with a mean age of 58.18±7.89 yearsand a male to female ratio 3:2. The mean IOP,C/D area ratio, RNFL and GCC thickness were 23.03±7.36 mmHg,0.86±0.13, 80.71±18.24 µ, and80.91±16.24 µ, respectively. There was a statistical significant positive correlation of high probability between the patients’ average GCC thickness and the average total , superior, inferior, temporal half, and temporal quadrant RNFL thickness. (P < 0.001) The superior and inferior average GCC thickness each showed a positive correlation withaverage total, superior, and inferior RNFL thickness. (P Value<0.001).

Conclusions:

SD-OCT can detect early glaucomatous changes affecting the RNFL and the retinal ganglion cells. There is a strong positive correlation between the RNFL thickness and the GCC thickness in patients with POAG.

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