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Monitoring neovascular AMD with split spectrum amplitude decorrelation angiography (SSADA)

Session Details

Session Title: AMD III

Session Date/Time: Sunday 20/09/2015 | 11:00-13:00

Paper Time: 12:04

Venue: Athena

First Author: : G.Donati SWITZERLAND

Co Author(s): :    C. Pournaras              

Abstract Details

PURPOSE:We investigated if combining Split Spectrum Amplitude Decorrelation Angiography (SSADA) with spectral domain optical coherence tomography (sOCT), could be a valauable alternative to Fluoresccein angiography (FA) and Indocyanine Green Angiography (ICG) coupled to sOCT to diagnose and follow-up neovascular AMD.


Seventy consecutive eyes (65 patients) diagnosed with neovascular AMD (50 active and 20 inactive cases) were investigated with SSADA, sOCT, FA and ICG.


We looked for Retinal oedema, subretinal fluid, hyperreflective outer retina points on sOCT. Choroidal neovascularization (CNV) or leakage on FA, CNV on ICG and on SSADA. The various imaging modalities were matched togheter. SOCT associated to SSADA was compared to sOCT associated to FA and ICG.


CNV was imaged with SSADA in 90% of the active cases. It persisted to some extent in 60% of the inactive cases. ICG was able to show the CNV in 95% of the cases. FA showed either the CNV or leakage in 85% of the cases. sOCT showed some exsudative findings in all the cases.


Combining SSADA to SOCT may prevent any need for dye injection in up to 90% to monitor patients suffering from neovascular AMD. As potentially fatal dye reaction, although very rare, still are a matter of concern in managing a non fatal disease as neovascular AMD, SSADA associated to sOCT will represent the future standard imaging in neovascular AMD.

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