london euretina
retina race

Effects of intravitreal dexamethasone implant on retinal oxygen saturation and retrobulbar blood velocity in macular edema secondary to retinal vein occlusion

Session Details

Session Title: Vascular Diseases and Diabetic Retinopathy IV

Session Date/Time: Sunday 20/09/2015 | 09:00-10:30

Paper Time: 09:40

Venue: Athena.

First Author: : K.Eibenberger AUSTRIA

Co Author(s): :    S. Rezar   D. Schmidl   R. Told   U. SchmidtErfurth   L. Schmetterer   S. Sacu

Abstract Details

PURPOSE:To investigate the effects of intravitreal Dexamethasone treatment (Ozurdex®) on retrobulbar blood velocity and oxygen saturation in retinal vessels in patients with macular edema (ME) due to either central- (CRVO) or branch retinal vein occlusion (BRVO) after 6 months.

Setting:

In this prospective non-randomized clinical trial, 40 eyes of 39 patients with ME due to RVO (25 BRVO and 15 CRVO), were recruited at the Department of Ophthalmology, Vienna General Hospital.

Methods:

The patients were followed-up monthly until six months after initial visits and one week following each Ozurdex® treatment. At every visit a complete ophthalmologic clinical examination, including ETDRS visual acuity (VA), indirect biomicroscopy and SD-OCT was performed. Retrobulbar blood velocity using color doppler imaging and oxygen saturation using a Retinal Vessel Analyzer were compared.

Results:

Mean VA at baseline in patients (m:f=25:15, mean age:69.5±12.1years) was 64±15 letters and increased significantly to 71±16 letters ETDRS at 6 months (p<0,05). Mean CRT was 533±153m at baseline and decreased to 303±77m after 6months (p<0,05). Retinal artery diameters (baseline: 102±2 month 6: 101±19; p=0,79) and oxygen saturation (BSL: 96±4 vs. 6months: 94±3; p=0,361) did not change significantly. In veins the vessel diameter (BSL: 152±21, 6mo: 138±17; p=0,078) and the retinal oxygenation (bsl: 78±9, 6mo: 74±9; p=0,091) showed a decrease over time.

Conclusions:

Intravitreal dexamethasone seems to be effective in the treatment of ME secondary to RVO with regard to vision and macular thickness. Furthermore, our results show that intravitreal Dexamethason may have a vasoconstrictive effect on retinal veins in eyes with ME secondary to RVO.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email: euretina@euretina.org

Privacy policyHotel Terms and Conditions Cancellation policy