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Retinal and choroidal thinning in diabetic patients with and without diabetic retinopathy: a new biomarker

Session Details

Session Title: Vascular Diseases and Diabetic Retinopathy III

Session Date/Time: Saturday 19/09/2015 | 16:30-18:00

Paper Time: 17:42

Venue: Clio

First Author: : J.Montero SPAIN

Co Author(s): :    J. RuizMoreno   J. Ruiz-Medrano   J. Araiz        

Abstract Details

PURPOSE:To report choroidal and internal retinal thinning in eyes with diabetic retinopathy (DR).

Setting:

Multicenter, prospective, non interventional study

Methods:

Fifteen consecutive diabetic patients with DR (Group 1), 15 consecutive diabetic patients without DR (Group 2) and 15 consecutive healthy controls matched for age and axial length were evaluated. Both eyes were examined. Exclusion criteria were previous treatment by intraocular drugs, ocular conditions other than DR and refractive error ≥ 6 dioptres. Full ophthalmic examination and Heidelberg Spectralis spectral domain optical coherence tomography (SDOCT) were performed. Specifically, automatic retinal layer segmentation of a 6×6mm, 64 horizontal B-scan lines macular scan centred on the fovea, and manual choroidal layer segmentation of vertical and horizontal 9 mm cross-hair scan (1536 A-scans) centred on the fovea, were performed.

Results:

A significant decrease of mean choroidal thickness was found in Group 1 vs. Groups 2 and 3. Similarly, mean retinal nerve fibre layer and ganglion cell layer thickness was reduced in Group 1 vs. Groups 2 and 3. However, inner nuclear layer was thicker in Group 1.

Conclusions:

Decreased choroidal and inner retinal thickness was found in diabetic patients with DR, suggesting that choroidal vasculature alteration and retinal neurodegeneration are early events in diabetic retinopathy. Automatic retinal and choroidal layer segmentation by SDOCT may be a useful biomarker for DR.

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