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Retinal Nerve Fiber Layer Thickness in early-stage Diabetic Retinopathy with Vitamin D deficiency

Session Details

Session Title: Vascular Diseases and Diabetic Retinopathy III

Session Date/Time: Saturday 19/09/2015 | 16:30-18:00

Paper Time: 17:10

Venue: Clio

First Author: : O.Ateş TURKEY

Co Author(s): :    A. GUNGOR   H. BILEN           

Abstract Details

PURPOSE:To evaluate retinal nerve fiber layer (RNFL) thickness in early stage DRP patients with vitamin D deficiency (VDD) and a early stage DRP patients without VDD


This study made a comparison of 50 patients with early-stage DR with VDD (group 1) and 50 patients with early stage DR without VDD (group 2).


All patients were examinated by same Ophthalmolog. Mean RNFL thickness thickness were determined by OCT. The same ophthalmologist performed the OCT imaging in all subjects. Vitamin D levels were measured by using a radioimmunoassay in all patients. VDD was defined, in accordance with the general standards, as having 25(OH)D levels less than 20 ng/ml


There was no significant difference between the groups in terms of age and sex distribution (p>0.05). The mean serum 25(OH)D concentration of group 1 was significantly lower than in group 2 (p<0.001). The mean RNFL thickness of group 1 was significantly thinner than that of group 2 (p < 0.001). A significant relationship between the mean RNFL thickness and serum 25(OH)D concentrations was observed in group 1 (p < 0.001)


İt demonstrated that vitamin D functioned as a neuroprotective component for optic nerves. Low serum 25(OH)D concentrations contribute to RNLF thinning in early stage DRP patients with VDD.

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