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To assess the retinal structure and function in patients on hydroxychloroquin (HCQ)

Session Details

Session Title: Imaging III

Session Date/Time: Saturday 19/09/2015 | 16:30-18:00

Paper Time: 17:18

Venue: Athena.

First Author: : D.Bhanushali INDIA

Co Author(s): :    S. Dabir   S. Mangalesh   P. Mahendradas   N. Yadav   R. Shetty  

Abstract Details

PURPOSE:Retinal toxicity represents the major and potentially most serious irreversible side effect of HCQ treatment. Most patients are asymptomatic, however, by the time clinical damage is appreciated, there may be irreversible damage to retina. Hence adaptive optics and microperimetry may be diagnostic tools to detect early and subtle toxicity.

Setting:

Narayana Nethralaya Super Speciality Eye Hospital and Post Graduate Teaching Institute, Bangalore

Methods:

Ten patients on HCQ who came to the retina clinic were included. They underwent a comprehensive ophthalmic examination, including a dry eye evaluation. All subjects underwent assessment with the Tonoref RKT-7000 autorefractometer, Nidek, non-contact biometry (IOL master; Carl Zeiss Meditec, Germany) for axial length, auto fluorescence and spectral-domain optical coherence tomography (Spectralis, Heidelberg) and microperimetry (MAIA, Centervue, Italy). A compact AO retinal camera prototype, the rtx1 (Imagine Eyes, Orsay, France), was used to image the photoreceptor layer

Results:

Ten eyes of 10 patients (2 male and 8 female) on HCQ, between the age group of 35-65 years were compared to 10 eyes of age matched controls. The mean cone count at two degrees was 21230 +/- 6836 among the cases and 23555+/- 5003 in the control group (p= 0.216).At 3 degrees the mean cone count among the cases was 20405 +/- 4744 and 20498+/- 3092 in control group (p=0.953). The average threshold and macular integrity of the cases was found to be 27.95 and 52.75 which was found to be significantly different from that of the control group 29.98 and 10.79 (p=0.005)

Conclusions:

Adaptive optics assessment of the photoreceptor mosaic and microperimetry may be a more sensitive tool to detect the subtle onset of retinal toxicity before it is manifested clinically

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