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Photoreceptor layer restoration speed as a new predictor of visual outcome after macula-off primary rhegmatogenous retinal detachment

Session Details

Session Title: Imaging III

Session Date/Time: Saturday 19/09/2015 | 16:30-18:00

Paper Time: 16:38

Venue: Athena.

First Author: : D.Velazquez Villoria SPAIN

Co Author(s): :    A. Boixadera Espax   V. Martinez Castillo           

Abstract Details

PURPOSE:To evaluate the correlation between Photoreceptor-layer restoration speed and visual function after successful repair of primary macula off rhegmatogenous retinal detachment (RRD).

Setting:

Prospective, consecutive, observational case series. Participants: Sixty-five eyes of 65 consecutive patients with macula off RRD after successful surgical repair by a pars plana vitrectomy (PPV) alone and gas tamponade

Methods:

Sixty-five patients diagnosed with macula off primary RRD were imaged using a Spectral Domain optical coherence tomography (SD-OCT) after performing a successful reattachment surgery. Images were acquired in the follow-up visits 1, 3, 6 and 12 months. Main outcome measures: Data analysis of images obtained by SD-OCT in the follow-up visits and best corrected visual acuity (BCVA). Photoreceptor Layer restoration speed was defined as the celerity of restoration of the External Limiting Membrane–line (ELM) and Ellipsoid-line (EL) signal in the serial SD-OCT images performed at 1,3, 6 and 12 months.

Results:

ELM line was disrupted in 36,9% of eyes at 1 month, 15,4% of eyes at 3 months, 10,8% of eyes at 6 months and 7,7% of eyes at 12 months after the surgery. EL signal was disrupted in 72,3% of eyes at 1 month, 44,6% of eyes at 3 months, 36,9% of eyes at 6 months and 29,2% of eyes at 12 months after the surgery. Multivariate analysis showed that final BCVA was significantly correlated with the integrity of the photoreceptor Ellipsoid-line and ELM signals (at 1st month: r=0,685; P<0,001; at 3rd month: r=0,764, P<0,001; at 6th month: r=0,708; P<0,001; and 12th month after surgery: r=0,555; P<0,001) and foveal thickness (at 1st month: r=0,434, P<0,001; 3rd month: r=0,428, P<0,001; at 6th month: r=0,614, P<0,001; and 12th month after surgery; r=0,580; P<0,001). Photoreceptor layer restoration speed significantly correlated with final BCVA (r=0,76; P:0,0001).

Conclusions:

Integrity of the foveal microstructure and foveal thickness may account for visual restoration in primary macula off RRD repaired by PPV alone. Photoreceptor layer restoration speed may be used as a new predictor of final BCVA these patients.

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