Session Title: Imaging II
Session Date/Time: Friday 18/09/2015 | 16:30-18:00
Paper Time: 17:42
First Author: : L.Toto ITALY
Co Author(s): : A. Mastropasqua A. Mastropasqua P. Mattei E. Borrelli L. Mastropasqua
PURPOSE:to evaluate parafoveal vessel density (PVD) of the two major retinal vascular plexuses by means of optical coherence tomography angiography (OCT-A) in diabetic patients with or without diabetic retinopathy (DR) and in healthy subjects.
Ophthalmology Clinic, High-Tech National Center in Ophthalmology, Department of Medicine and Aging Sciences, University “G. d’Annunzio” Chieti-Pescara, Italy
80 diabetic patients (80 eyes) were included in this observational study and were divided according to the International Clinical Severity Scale for DR : group 1 (20 eyes) with no signs of DR, group 2 (20 eyes) with mild non proliferative diabetic retinopathy (NPDR), group 3 (20 eyes) with moderate and severe NPDR, group 4 (20 eyes) with proliferative diabetic retinopathy (PDR). Group 5 of healthy subjects (20 eyes) was chosen as control. PVD of the superficial and deep plexuses was measured by means of high speed and high resolution spectral-domain optical coherence tomography (SD-OCT) XR Avanti ® (Optovue, Inc, Fremont CA, USA) with split-spectrum amplitude decorrelation angiography (SSADA) algorithm.
No significant differences were observed between subjects with mild NPDR, diabetic patients without DR signs, and healthy subjects.
OCT-A is a new dyeless method for imaging retinal microcirculation in healthy and diseased eyes showing progressive reduction of PVD in both superficial and deep plexus at increasing diabetic retinopathy severity.