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Parafoveal vessel density evaluation in diabetic retinopathy using optical coherence tomography angiography (OCT-A)

Session Details

Session Title: Imaging II

Session Date/Time: Friday 18/09/2015 | 16:30-18:00

Paper Time: 17:42

Venue: Thalie.

First Author: : L.Toto ITALY

Co Author(s): :    A. Mastropasqua   A. Mastropasqua   P. Mattei   E. Borrelli   L. Mastropasqua  

Abstract Details

PURPOSE:to evaluate parafoveal vessel density (PVD) of the two major retinal vascular plexuses by means of optical coherence tomography angiography (OCT-A) in diabetic patients with or without diabetic retinopathy (DR) and in healthy subjects.

Setting:

Ophthalmology Clinic, High-Tech National Center in Ophthalmology, Department of Medicine and Aging Sciences, University “G. d’Annunzio” Chieti-Pescara, Italy

Methods:

80 diabetic patients (80 eyes) were included in this observational study and were divided according to the International Clinical Severity Scale for DR : group 1 (20 eyes) with no signs of DR, group 2 (20 eyes) with mild non proliferative diabetic retinopathy (NPDR), group 3 (20 eyes) with moderate and severe NPDR, group 4 (20 eyes) with proliferative diabetic retinopathy (PDR). Group 5 of healthy subjects (20 eyes) was chosen as control. PVD of the superficial and deep plexuses was measured by means of high speed and high resolution spectral-domain optical coherence tomography (SD-OCT) XR Avanti ® (Optovue, Inc, Fremont CA, USA) with split-spectrum amplitude decorrelation angiography (SSADA) algorithm.

Results:

No significant differences were observed between subjects with mild NPDR, diabetic patients without DR signs, and healthy subjects.

Conclusions:

OCT-A is a new dyeless method for imaging retinal microcirculation in healthy and diseased eyes showing progressive reduction of PVD in both superficial and deep plexus at increasing diabetic retinopathy severity.

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