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Does intravitreal anti-VEGF treatment prevent vitreofoveal separation

Session Details

Session Title: Imaging II

Session Date/Time: Friday 18/09/2015 | 16:30-18:00

Paper Time: 17:10

Venue: Thalie.

First Author: : G.Murthy INDIA

Co Author(s): :    G. Menon   M. Chandran           

Abstract Details

PURPOSE:There are reports of increased incidence of VMT assessed by Oct, in wet ARMD patients as well as inverse relationship between PVD and ARMD. CNVM patients require a number of anti VEGF intravitreal injections for its treatment.How ever there are not many studies on the effect of antivegf on the intact vitreofoveal interface. The purpose of this study was to assess the effects of anti VEGF injections on the vitreofoveal interface to see if it induces seperation or worsens the same or has no effect on it, in those who have intact adhesion as demonstrated by OCT.


Patients who had recieved a minimum of 5 antiVEGF injections at a tertiary center


Retrospective interventional case series of 50 eyes in 48 patients who had intact vitreofoveal adhesion as demonstrated by OCT before treatment. Patients received repeated antivegf treatment for mostly wet ARMD and 5 patients for BRVO. Vitreofoveal interface was monitored with serial optical coherence tomography scans before , during and after treatment.


The mean age of the patients were years(range 58-96). 35 patients received injections for wet ARMD, -5 for BRVO. Ranibizumab was used in 30 eyes and bevacizumab in 20 eyes. The number of injections per eye varied from 5-23. The mean follow-up was (range 6-36 months). None of the eyes had occurrence of vitreo foveal seperation. 15 eyes had OCT demonstrable strengthening of vitreo foveal adhesion/VMT.


The vitreous macular adhesion seems to be either kept intact or strengthened by repeated intravitreal antivegf treatment.

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