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Relationship between diabetic macular edema and deep capillary plexus microaneurysms evaluated by en face OCT angiography

Session Details

Session Title: Imaging II

Session Date/Time: Friday 18/09/2015 | 16:30-18:00

Paper Time: 17:02

Venue: Thalie.

First Author: : M.Nozaki JAPAN

Co Author(s): :    N. Hasegawa   N. Takase   M. Yoshida   Y. Ogura     

Abstract Details

PURPOSE:To study the association between the location of microaneurysms (MAs) detected by En Face OCT angiography (AngioVue, Avanti OCT, Optovue) and macular edema detected by SD-OCT (Cirrus HD-OCT, Carl Zeiss Meditec) in patients with diabetic macular edema.


This study was carried out retrospectively in Nagoya City University Hospital, Nagoya, Japan.


Retrospective chart review of 10 eyes from 9 patients with clinically significant macular edema who have undergone fundus examination including En Face OCT angiography (6X6 mm) and Macular Cube (512X128). Each images of superficial capillary plexus layer and deep capillary plexus layer were overlaid onto the image of topographic map (6X6 mm) using Photoshop, and the area of edema, number of MAs were measured by Image J software (NIH). The association between the number of MAs and macular edema were evaluated in each capillary plexus layer.


Average number of MAs detected by En Face OCT angiography were 18 (10-28) in the whole capillary plexus, and 76.5 ± 9.7 % of MAs (7-27) were located in deep capillary plexus layer. But in the area where retinal thickness were more than 400 μm, 93.6 ±8.6% of MAs were found in deep capillary plexus layer, and there was a significant difference (p=0.01). The macular volume and the number of MAs existing deep capillary plexus layer in edema were also significantly correlated (r=0.78,p=0.01).


Our study demonstrated a novel association between the patterns of MAs detected by En Face OCT angiography and diabetic macular edema. The MAs located in deep capillary plexus layer might be responsible for pathogenesis of diabetic edema.

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