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Measurement of choroidal thickness among young healthy ‎Egyptians by EDI-OCT and ‎its correlation with blood pressure

Session Details

Session Title: Imaging II

Session Date/Time: Friday 18/09/2015 | 16:30-18:00

Paper Time: 16:38

Venue: Thalie.

First Author: : Z.Eldaly EGYPT

Co Author(s): :    S. Kedwany   N. Magdy           

Abstract Details

PURPOSE:To measure the choroidal thickness and its location-based profile in young ‎healthy ‎Egyptian subjects and the correlation with age and blood pressure.‎

Setting:

A prospective observational study was conducted in Tiba Eye Center (private practice), ‎Assiut, Egypt from January 2014 till September 2014.‎

Methods:

A prospective observational study recruited 35 young volunteers with no ophthalmic or ‎systemic disease. They were evaluated by Enhanced Depth Imaging (EDI) technology of ‎Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany). Eyes with high myopia ‎‎(exceeding -6 D), ‎retinal/choroidal disease, and previous ocular trauma were excluded. Two ‎line scans (vertical and horizontal), centered on the fovea, were taken with 100-averaged ‎frames. Choroidal thickness was defined as the vertical distance from ‎the high reflective line of ‎Bruch’s membrane to the high reflective ‎line of the inner surface of the sclera. Choroidal ‎thickness were measured in 9 different locations, central sub-foveal thickness, 1 mm and 2 ‎mm superior, inferior, temporal and nasal to foveal center. The measurements were ‎performed using the Heidelberg Eye Explorer ‎software (Heidelberg Engineering, Heidelberg, ‎Germany). ‎Blood pressure and choroidal thickness were measured at the same setting and ‎day time (afternoon) for all patients by a single experienced physician (Z. E.) to avoid possible ‎diurnal variation in ‎choroidal and retinal thickness.

Results:

Sixty three eyes were evaluated. Mean age of the volunteers was 25.3 ± ‎‎5.2 years (20-37 ‎years). Mean central sub-foveal choroidal thickness was 297.1 ± 92.2 um. ‎Mean ‎choroidal thickness 1 mm temporal, nasal, superior and inferior to foveal center ‎were ‎‎293.2 ± 55.2 um, 296 ±73.3 um, 326.2 ± 63.7 um and 306.8 ± 62.2 um respectively. ‎Mean ‎choroidal thickness 2 mm temporal, nasal, superior and inferior to foveal center ‎were 262.4 ± ‎‎104.9, 251.3 ± 90.3 um, 331.5 ± 53.6 um and 307.7 ± 56.9 um respectively. ‎Mean central foveal ‎thickness was 229.9 ± 7.1 um.There are variable positive but non-‎significant correlation between mean BP and mean ‎choroidal thickness in temporal, nasal, ‎superior and inferior sectors (r = 0.169, 0.025, 0.38 and ‎‎0.41 respectively). There are ‎variable negative but non-significant correlation between age and ‎mean choroidal ‎thickness in temporal, nasal, superior and inferior sectors (r = 0.169, 0.025, 0.38 ‎and 0.41 ‎respectively) and positive non-significant correlation between age and mean ‎choroidal ‎thickness in superior sectors.

Conclusions:

EDI-OCT is an important tool in the evaluation of choroidal thickness. Choroidal ‎thickness ‎profile depends upon its location. Correlation between blood pressure and ‎choroidal thickness ‎could be a key to many unanswered questions in retinal vascular ‎diseases. To our knowledge, ‎this is the first normative database for choroidal thickness ‎among Egyptian population.‎

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