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Dietary B vitamins, genetic susceptibility, and 13 year incidence of geographic atrophy

Session Details

Session Title: AMD II

Session Date/Time: Friday 18/09/2015 | 14:30-16:00

Paper Time: 14:54

Venue: Calliope.

First Author: : B.Merle UNITED STATES

Co Author(s): :    R. Silver   B. Rosner   J. Seddon        

Abstract Details

PURPOSE:Higher intake of B vitamins could help reduce progression to advanced stages of age-related macular degeneration (AMD), and these associations may be modified by genetic susceptibility. Our objective is to investigate associations between dietary B vitamins, genes related to AMD, and progression to geographic atrophy (GA).

Setting:

We conducted a prospective analysis using data from the Age-Related Eye Disease Study. We included 2525 participants, representing 4663 eyes.

Methods:

Eyes without advanced AMD at baseline were evaluated for progression to GA. Baseline data for demographic and behavioral covariates, including age, gender, smoking, body mass index and supplement use, were collected using questionnaires. Dietary data were collected from food frequency questionnaires at baseline. B vitamins (g/day or μg/day) were transformed using Willett’s residual method and were adjusted for total energy intake (kcal/day) and gender. The adjusted B vitamins were ranked into gender-specific quintiles. Ten genetic loci in 7 genes (CFH, ARMS2, C2, C3, CFB, COL8A1, and RAD51B) were examined. Survival analysis was used to assess individual eyes for associations between incident GA and dietary intake of B vitamins, as well as interaction effects between B vitamins and genetic variation on risk of AMD.

Results:

We found a significant trend for reduced risk of progression to GA with increasing intake of B1 vitamin and folate, after adjusting for demographic, behavioral and ocular covariates, (p trend=0.049 and p trend=0.02, respectively). These trends remained significant after adjustment for genetic covariates (p trend=0.03; Hazard Ratio (HR)=0.70; 95 % Confidence Interval (CI)=0.52-0.95 (quintile (Q) 5 vs. Q1) and p trend=0.01; HR=0.73; 95 %CI=0.54-0.99). Vitamins B1, B2 and folate were significantly associated with a lower risk of incident GA among subjects homozygous for the C3 rs2230199 (R102G) non-risk genotype (CC) (p trend<0.0001; p trend=0.001 and p trend=0.0002, respectively). These vitamins were not associated with progression to GA among subjects carrying the risk allele (G).

Conclusions:

High intake of vitamin B1 and folate were associated with a reduced risk of progression to GA. This relationship could be modified by genetic susceptibility, particularly related to the C3 genotype.

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