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Evaluation of corneal endothelial cell damage after vitreoretinal surgery: comparison of different endotamponades

Session Details

Session Title: Vitreoretinal Surgery III

Session Date/Time: Friday 18/09/2015 | 14:30-16:00

Paper Time: 14:30

Venue: Athena

First Author: : C.Küçükerdönmez TURKEY

Co Author(s): :    E. Cinar   M. Zengin   E. Erakgun        

Abstract Details

PURPOSE:To evaluate the corneal endothelial cell(EC) damage after vitreoretinal surgery and compare the results with different tamponades


Izmir University Faculty of Medicine, Department of Ophthalmology


This prospective controlled study included 45 eyes of 45 patients (24 females, 21 males), who underwent pars plana vitrectomy with gas (sulphur hexafluoride, SF6, 20%) or silicone oil (SO) tamponade. Patients were assigned to one of three groups: group 1 (phakic, 20% SF6 gas), group 2 (pseudophakic, 20% SF6 gas), and group 3 (phakic, SO).Mean endothelial cell density(MCD), mean cell area(MCA), coefficient of variation in cell size(CV), and percentage of hexagonal cells(HC) values were measured using a non-contact specular microscope(SP-2000P;Topcon,Japan) at baseline and 3 months after surgery. The fellow eye of each patient was used as a control.


Group 2, which had the lowest baseline MCD and MCA values, was found to be different than groups 1 and 3 (p=0.028 and 0.022, respectively). At 3 months postoperatively, all groups showed significantly lower MCD, HC and CV values than baseline(all p<0.05). The mean changes in MCD at 3 months after surgery were 3.8±2.8%, 8.0±7.5%, and 4.6±5.4% in groups 1, 2, and 3, respectively. The mean MCD changes in the fellow eyes were 0.31±1.41% in group 1, -0.63±1.90% in group 2, and 0.14±0.52 in group 3 at 3 months postoperatively(p>0.05 for all).


Our findings revealed that corneal EC damage may occur after vitreoretinal surgery with gas or silicone oil tamponade. Eyes that had undergone previous cataract surgery were more vulnerable to EC loss than phakic eyes, supporting the protective effect of an intact lens.

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