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Asymmetry in macular choroidal thickness profile between both eyes in a healthy population measured by swept-source optical coherence tomography

Session Details

Session Title: New Drug Treatment and Technology I

Session Date/Time: Friday 18/09/2015 | 11:00-12:30

Paper Time: 11:16

Venue: Thalie.

First Author: : J.RuizMoreno SPAIN

Co Author(s): :    J. RuizMoreno   J. Ruiz-Medrano   I. FloresMoreno   P. PenaGarcia   J. Montero   J. Duker

Abstract Details

PURPOSE:To determine the difference in macular choroidal thickness (CT) profile between each eye in a healthy population using swept-source optical coherence tomography (SS-OCT).

Setting:

Universidad de Castilla-La Mancha

Methods:

Cross-sectional, non-interventional study. 140 eyes from 70 healthy patients with spherical equivalent (SE) between ±3D and with difference ≤0.25D between eyes, were scanned using a SS-OCT (Topcon Corporation, Japan). A horizontal CT profile of the macula was created in both eyes by manually measuring the subfoveal CT (SFCT) from the posterior edge of retinal pigment epithelium (RPE) to the choroid/sclera junction. Three determinations were performed at successive points 1000 μm nasal to the fovea and five more temporal to the fovea. The differences in CT between both eyes were analyzed.

Results:

Mean age was 25.4±19.9 years (from 4 to 75). The mean SE was 0.18±1.37 D (from -3 to +3). Mean macular nasal CT was thicker in the right eye (RE) than in the left eye (LE), (228.11±69.23 μm vs. 212.27±62.71 μm; p= 0.0002; Student t test paired data). Mean SFCT and mean temporal CT was not different between RE vs. LE. No statistically significant differences were observed comparing SE in the RE vs. LE. Mean nasal CT by sex, was also thicker in the RE vs. LE (men, 226.97±61.56 μm vs. 209.87±60.31 μm; women 229.63±79.39 μm vs. 215.47±66.68 μm, p=0.003 and p=0.03 respectively; Student t test paired data). At each nasal determination CT in the RE was thicker than LE (N1: 283.72±81.10 μm vs. 269.76±75.81μm (p= 0.001); in N2: 230.45±73.47 μm vs. 211.33±66.92 μm (p= 0.0002) and in N3: 170.16±61.00 μm vs. 155.72±53.87 μm (p= 0.008) respectively).

Conclusions:

To our knowledge, this is the first report suggesting thicker macular nasal choroid in the right eye compared to the left eye, meanwhile SFCT and temporal CT was not different between both eyes.

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