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Sterile cluster endophthalmitis after intravitreal avastin injection

Session Details

Session Title: Vitreoretinal Surgery II

Session Date/Time: Friday 18/09/2015 | 08:00-10:00

Paper Time: 09:44

Venue: Calliope

First Author: : S.Sinha INDIA

Co Author(s): :    C. Bhatt              

Abstract Details

PURPOSE:To report a series of patients with sterile endophthalmitis after intravitreal bevacizumab injection from a single vial of bevacizumab


Tertiary Eye care hospital in Kolkata, India


Records of 15 eyes with severe inflammation after intra vitreal injections from a single vial were evaluated. Fifteen eyes of 15 patients in one day were treated with one batch. The vial was opened on the day of injection. We used commercially available bevacizumab (100 mg/4 ml) kept at 4°C. All the patients reported with loss of vision and presented with hypopyon and vitreous haze within 48 hrs of injection. All cases were admitted to the ward and underwent vitreous tap for direct smear and culture along with vitrectomy


All patients underwent vitrectomy with 72 hrs of presentation. Vitreous tap was negative for any organism both in smear and culture. All the patients regained pre injection visual acuity 2 weeks after vitrectomy. The avastin vial was sent to the manufacturing company which reported the contents to be spurious containing different chemicals


We report a cluster of sterile endophthalmitis following intravitreal injection of bevacizumab from the same batch of bevacizumab.The suspected vial has been proved to be a counterfeit based on the report of the manufacturing company.

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