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Trends in pattern of HLAB27 uveitis in a tertiary eye department in the United Kingdom

Session Details

Session Title: Miscellaneous

Session Date/Time: Thursday 17/09/2015 | 11:00-12:30

Paper Time: 12:12

Venue: Athena.

First Author: : I.Choudhuri UNITED KINGDOM

Co Author(s): :    P. Kumar   T. Empeslidis   K. Thanos   E. Drakos   A. Pradeep  

Abstract Details

PURPOSE:The study aims to describe the characteristics of HLAB27 positive uveitis patients seen by a tertiary eye department in United Kingdom


Department of ophthalmology, The University Hospitals of Leicester, The United Kingdom


This was a retrospective analysis of the clinical records of consecutive new cases of HLAB27 that presented to the Uveitis subspecialty clinic between 2011 and 2014. Data collected included demographics, clinical and laboratory findings. Diagnoses were based on standardised clinical history, ophthalmological examination and investigations.


There were 73 new cases (105 eyes) of HLAB27 positive uveitis, comprising 11.68% of 624 new uveitis patients. The median age of diagnosis was 35 years, patients in the age group of 19-78 years. The gender distribution showed 34 patients were males and 39 females. 13 patients belonged to Asian race and 56 were Caucasians. 56% of cases presented with unilateral eye involvement with slight female preponderance. 87.6% had anterior uveitis with 38% showing chronicity. 79% of the patients had better than 0.3LogMar acuity in the affected eye on presentation. The most common systemic disease associated was Ankylosing Spondylitis in 31.88% of the patients. Other systemic diseases associated were Diabetes type II, Psoriatic Arthritis, Seronegative Arthritis, Crohn’s Disease, Rheumatoid Arthritis and Gout Disease. Cataract formation was the most common complication in 15.94%, followed by posterior synechiae, ocular hypertension, secondary glaucoma, and cystoid macular edema. In the majority of patients, the uveitis was controlled only with local treatment and visual acuity remained stable after treatment but 28.7% of patients needed systemic immunosuppression to control the disease, 34.2% of the affected eyes did not develop any complications


Many cases of HLAB27 associated uveitis in our series had no associated systemic disease. HLA-B27 typing in patients with anterior uveitis is both an important diagnostic and prognostic investigation. This case series emphasizes the high incidence of Ankylosing Spondylitis in patients, who presents with uveitis associated with positive HLA B27 results. This result does play a key role of the ophthalmologists in identifying previously undiagnosed systemic diseases.

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