Session Title: AMD I
Session Date/Time: Thursday 17/09/2015 | 08:30-10:30
Paper Time: 09:10
First Author: : M.Lupidi FRANCE
Co Author(s): : G. Coscas F. Coscas J. Zerbib A. Dirani O. Semoun E. Souied
PURPOSE:To suggest a clinical distinction between idiopathic Polypoidal Choroidal Vasculopathy (PCV) and secondary polyps associated with neo-vascular age related macular degeneration (NV-AMD).
“Odeon Ophthalmology Center” and “Creteil University Hospital” (Paris, France)
Retrospective case series of 52 eyes of 52 consecutive patients (31 females and 21 males) diagnosed with PCV. Initial diagnosis was based on SLO-Indocyanine green angiography (ICGA) in association with Fluorescein angiography (FA) and Optical coherence tomography (OCT). All the data and images were analyzed in a masked fashion by four experienced examiners, in two different sessions: the first one to classify patients into the two hypothesized groups (idiopathic polyps or NV-AMD related polyps); the second one, following a pre-determined scheme, to describe objective features. The results obtained in each session underwent a cross multivariate analysis to identify statistically significant differences (p < 0.05) between the two groups.
The two groups were clinically different, based on FA (leakage origin [p=0.001] and presence of drusen [p=0.001]), ICGA (evidence of choroidal neovascularization [CNV] [p=0.001] and/or branching vascular network [BVN] [p=0.001]), OCT imaging (type of pigmented epithelium detachment [p=0.001], presence of BVN [p=0.001], and choroidal thickness [p=0.001]). Further significant differences were observed according to the location of lesion (uni or multifocal) [p=0.001], type of CNV [p=0.001], and best-corrected visual acuity (BCVA) [p=0.001].
Our study demonstrated clinical and statistically significant differences between idiopathic PCV and NV-AMD related polyps that could be considered as distinct entities. Although they share some similarities, mainly the sub-RPE location, the ability to identify a specific clinical pattern suggests a more specific therapeutic approach for these two entities.