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Acid violet 17 assisted peeling of the internal limiting membrane: first clinical experiences

Session Details

Session Title: Vitreoretinal Surgery I

Session Date/Time: Thursday 17/09/2015 | 08:30-10:30

Paper Time: 10:14

Venue: Apollon.

First Author: : H.Gerding SWITZERLAND

Co Author(s): :                  

Abstract Details

PURPOSE:Recently Acid violet 17 (ala purpleĀ®) was approved as a novel dye for intravital staining of the internal limiting membrane. So far no clinical reports are available beyond the level of in vitro- and in vivo-test in cell culture- and animal experiments.

Setting:

Institutional case series.

Methods:

Acid violet 17 was used in 53 eyes (53 patients, mean age 72.3+/-8.2 years) during vitreoretinal interventions in order to stain the ILM. Main indications were: epiretinal fibroplasias (n=43), macular hole (n=5), and other diseases (n=4).

Results:

Intraoperatively it was obvious that Acid violet 17 is selectively staining the ILM. The intensity score of the staining effect (2.6+/-0.7, maximum score: 5) was significantly better than that of brilliant blue (mean score 2.1+/-1.0, p<0.001). Adverse effects so far observed were: 1. a transient staining of hydrophilic intraocular lenses (12 of 29, 41%) and 2. a severe visual acuity loss in one of five cases with macular hole (preoperative visual acuity 0.2p, postoperatively counting fingers).

Conclusions:

Acid violet 17 provides an improved staining effect of the internal limiting membrane in vitreoetinal interventions. Staining of hydrophilic IOL was observed as a new complication of Acid violet 17 use. Clinical safety studies and long-term follow-up data are so far not available.

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