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Posters

Comparison of bevacizumab and ranibizumab in the treatment of macular edema due to retinal vein occlusion

Poster Details

First Author: R.Rothwell PORTUGAL

Co Author(s):    S. Fonseca   L. Ribeiro   L. Silva   M. Queirós   A. Brandão   L. Agrelos   0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

To compare ranibizumab and bevacizumab in the treatment of macular edema (ME) subsequent to retinal vein occlusion (RVO).

Setting:

Gaia Hospital, Portugal

Methods:

A comparative, retrospective, non randomized study of 22 eyes of 22 patients with RVO and ME that were treated with on demand intravitreous injections of 0.5mg ranibizumab (n=12) and 1.25mg of bevacizumab (n=10) during a 6 month follow up period. The two main outcomes were the best corrected visual acuity (BCVA) and the reduction of central foveal thickness (CFT) at month 6.

Results:

In both groups there was an improvement in BCVA in months 1, 3 and 6 with no statistically significant difference between groups. In month 6 there was an improvement of 0.20 in the ranibizumab group and of 0.19 in the bevacizumab group in the Snellen decimal scale (p>0.05). The BCVA was ≥0,5 in 25% of patients in the ranibizumab group and in 20% of the bevacizumab group (p>0.05). The reduction of the CFT was 320.67μm in the ranibizumab group and 322.80μm in the bevacizumab group (p>0.05), without a statistically significant difference between groups. Retinal tears, retinal detachments or endophthalmitis did not occur after treatments. There were no systemic complications.

Conclusions:

In patients with ME secondary to RVO, treatment with bevacizumab and ranibizumab appears to be equally safe and effective. Multicentric randomized studies are necessary to corroborate our results.

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