First Author: V.Prabhu INDIA
Co Author(s): 0 0 0 0 0 0 0 0 0
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To report successful use of intravitreal bevacizumab (Avastin) in a young boy with choroidal neovascular membrane (CNVM) secondary to traumatic choroidal rupture .
A 8 year old boy presented with defective vision in right eye (RE) following blunt trauma 1 year back . No history of redness ,pain, watering . No history of any previous ocular intervention or treatment taken for same .
On examination BCVA in RE was hand movements close to face ; LE 6/6. The pupillary reactions were normal and slit-lamp biomicroscopic examination of anterior segment was normal in both eyes . Fundus examination of RE showed yellowish white to orange red streak shaped lesion annular to fovea with pigmented margins with retinal hemorrhage in the fovea. LE fundus examination was normal. A clinical diagnosis of RE active CNVM secondary to choroidal rupture ; LE was normal was made . BE IOP was normal . OCT RE confirmed diagnosis . Taking into consideration 1 year history and difficulty in predicting which will progress to permanent visual loss and which will regress without treatment, single injection of Bevacizumab (Avastin) in dose of 1.25mg (0.05ml) was administered intravitreally under aseptic precautions (after fully informed consent). No complication during or after procedure was noted.
Near complete regression of CNVM (hemmorhage) and BCVA in RE -- improved to 6/60 at last follow up at 6 months following the injection .
Intravitreal bevacizumab (Avastin) was safely injected in a case of pediatric traumatic CNVM with favourable outcome. Long term safety and appropriate dosage of lntravitreal bevacizumab needs to be studied.