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Analysis of patomechanism of diabetic retinopathy - a study of HbA1c, diabetic mellitus duration, endothelin-1, nitric oxide and retinal vessel calibre

Poster Details

First Author: A.Poli INDONESIA

Co Author(s):    H. Muhiddin   B. Manyyu               0   0 0   0 0   0 0   0 0

Abstract Details


To observe the expression of Endothelin-1 (ET-1) and Nitric Oxide (NO) as a result of ischemia and the role of HbA1c and duration of Diabetic Mellitus (DM) toward the calibre of retinal vessel.


Research was conducted at Wahidin Sudirohusodo Hospital and Celebes Eye Center in Makassar, Indonesia.


The research was an observational research with cross sectional design. Thirty subjects was measured by HbA1c, FBG current blood glucose, ET-1 and NO level, continued with fundus photographs to evaluate the severeness of Diabetic Retinopathy (DR). 8 men and 22 women were observed, consist of 9 non RD, 15 mild Non Proliferative DR (NPDR), 4 moderate NPDR and 1 severe NPDR. The mean level of HbA1c was 8.41±2.27 percent, the mean ET-1 level was 6.97±2.39 pg/ml and NO level was 2.08±0.75µM, the mean of retinal artery caliber is 1.14±0.14mm and the mean vein caliber is 1.57±0.64mm.


The result of the research indicated that the greater the severeness of DR, the wider retinal vein caliber (p=0.034). In addition, the higher level of serum NO, the greater severeness of DR (p=0.00) and the longer duration of DM, the wider retinal vein caliber (p=0.00). There is a tendency that the higher HbA1c levels, the narrower retinal artery caliber (p=0,248). There is a significant correlation between ET-1 level and the severness of DR (p=0.021), retinal artery caliber (p=-0.158) and retinal vein caliber (p=0.270).


It seems that the severeness of RD and retinal vessels caliber is more affected by the expression of NO compared to ET-1.

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