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Posters

Factors affecting disruption of the photoreceptor inner/outer segments in diabetic macular edema

Poster Details

First Author: T.Otani JAPAN

Co Author(s):    Y. Yamaguchi   S. Kishi               0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

Spectral-domain optical coherence tomography (SD-OCT) provides an assessment of the integrity of photoreceptor inner/outer segments (IS/OS). Disruption of IS/OS in the fovea affects visual acuity in diabetic macular edema (DME). We evaluated factors affecting the disruption of IS/OS in DME using SD-OCT.

Setting:

Department of Ophthalmology, Gunma University, School of Medicine

Methods:

Thirty-nine patients (54 eyes) with DME comprised the study population. SD-OCT was performed in all eyes, every 3 months, for 2 years. Eyes, with disruption of IS/OS at baseline, were excluded. The subjects were divided into two groups according to the survival rate of intact IS/OS within the foveal area (1.0 mm in diameter) at 2 years: Group A comprised 21 eyes with IS/OS less than 50%, and Group B contained 33 eyes with IS/OS over 50%. Visual acuity (VA), central macular thickness (CMT), the height of serous retinal detachment (SRD), and the thickness of cystoid macula edema (CME) at the fovea were averaged and evaluated.

Results:

In all 54 eyes, mean baseline VA decreased from 0.62 (20/32) to 0.51 (20/39) at 2 years (P<0.01). Mean baseline CMT decreased from 418 µm to 355 µm at 2 years (P<0.01). Mean VA at 2 years was 0.35 (20/57) in Group A (21 eyes) and 0.65 (20/31) in Group B (33 eyes) (P<0.01). Two-year mean CMT was 405 µm in Group A and 390 µm in Group B (P=0.76). During the observation periods, SRD was detected by SD-OCT in 20 eyes (95%) in Group A and in 33 eyes (55%) in Group B (P<0.01). Two-year mean height of SRD was 52 µm in Group A and 17 µm in Group B (P<0.001). Two-year mean thickness of CME was 145 µm in Group A and 146 µm in Group B (P=0.95).

Conclusions:

SRD associated with affecting disruption of the IS/OS in DME.

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