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Factors affecting disruption of the photoreceptor inner/outer segments in diabetic macular edema

Poster Details

First Author: T.Otani JAPAN

Co Author(s):    Y. Yamaguchi   S. Kishi               0   0 0   0 0   0 0   0 0

Abstract Details


Spectral-domain optical coherence tomography (SD-OCT) provides an assessment of the integrity of photoreceptor inner/outer segments (IS/OS). Disruption of IS/OS in the fovea affects visual acuity in diabetic macular edema (DME). We evaluated factors affecting the disruption of IS/OS in DME using SD-OCT.


Department of Ophthalmology, Gunma University, School of Medicine


Thirty-nine patients (54 eyes) with DME comprised the study population. SD-OCT was performed in all eyes, every 3 months, for 2 years. Eyes, with disruption of IS/OS at baseline, were excluded. The subjects were divided into two groups according to the survival rate of intact IS/OS within the foveal area (1.0 mm in diameter) at 2 years: Group A comprised 21 eyes with IS/OS less than 50%, and Group B contained 33 eyes with IS/OS over 50%. Visual acuity (VA), central macular thickness (CMT), the height of serous retinal detachment (SRD), and the thickness of cystoid macula edema (CME) at the fovea were averaged and evaluated.


In all 54 eyes, mean baseline VA decreased from 0.62 (20/32) to 0.51 (20/39) at 2 years (P<0.01). Mean baseline CMT decreased from 418 µm to 355 µm at 2 years (P<0.01). Mean VA at 2 years was 0.35 (20/57) in Group A (21 eyes) and 0.65 (20/31) in Group B (33 eyes) (P<0.01). Two-year mean CMT was 405 µm in Group A and 390 µm in Group B (P=0.76). During the observation periods, SRD was detected by SD-OCT in 20 eyes (95%) in Group A and in 33 eyes (55%) in Group B (P<0.01). Two-year mean height of SRD was 52 µm in Group A and 17 µm in Group B (P<0.001). Two-year mean thickness of CME was 145 µm in Group A and 146 µm in Group B (P=0.95).


SRD associated with affecting disruption of the IS/OS in DME.

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