First Author: R.Narayanan INDIA
Co Author(s): J. Chhablani A. Sudhalkar I. Kozak G.B. Jonnadula P.S. Rao A. Venkata 0 0 0 0 0 0 0 0 0
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To evaluate choroidal thickness change in various grades of diabetic retinopathy in comparison to age-matched healthy subjects
Tertiary Eye Care Center
This prospective observational study included 227 eyes of 125 diabetic subjects (study group; 58 females) and 197 eyes of 110 age-matched healthy subjects (control group; 66 females). Collected data included age, gender, duration of diabetes, glycemic control, comprehensive ocular examination, fundus photography and choroidal thickness measurement on spectral domain ocular coherence tomography using enhanced depth imaging (EDI).
Mean age in the study group was 57.0 ± 9.37 years (43-73 years). The mean age was 41.48 ± 15.43 years in the control group. Diabetics with (252.8±55.6 microns) and without (261.71±51.8 microns) retinopathy had significantly thinner choroids when compared to the control group (281.7±47.7 microns; P=0.032). 74 of 227 eyes did not have any evidence of diabetic retinopathy, 89 eyes had features of non-proliferative diabetic retinopathy (NPDR) and 33 eyes had treatment naïve proliferative diabetic retinopathy (PDR). 31 PDR eyes had received previous laser photocoagulation Diabetic patients without retinopathy had a greater subfoveal choroidal thickness (SFCT) than diabetics with retinopathy (p<0.001). Eyes with PDR (243.9±56.2 microns) had thinner SFCT than those with NPDR (238.98±111.23 microns). There was no difference in the SFCT between treated (laser photocoagulation done; 251.784±103.72 microns) and treatment naïve PDR (258.405±89.47 microns, p=0.23).
Control eyes had greater SFCT compared to diabetics with and without retinopathy. The thinning progressed with increasing severity of diabetic retinopathy. Choroidal thinning may contribute to diabetic retinopathy pathogenesis.