First Author: P.Kiryttopoulos GREECE
Co Author(s): A. Agorastos M. Charalambidis E. Kotsifou E. Paphianou M. Moschos I. Chatziralli 0 0 0 0 0 0 0 0 0
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To investigate the effect of vitamin E on oxidative stress, as expressed by serum malondialdehyde (MDA), in insulin-dependent type II diabetic patients with diabetic retinopathy (DR).
1Department of Internal Medicine, General Hospital of Veroia, Greece 2Department of Oncology, Specialized Anticancer Hospital 'Theageneio', Greece 3Laboratory of Electrophysiology, 1st Department of Ophthalmology, University of Athens, Greece 4Department of Internal Medicine, Papanikolaou Hospital, Greece
282 insulin-dependent type II diabetic patients, 138 male and 144 female, aged between 50-70 years, participated in the study. Patients presented cardiac failure stage I (according to NYHA) without myocardial infarction history and/or kidney failure stage I without diabetic nephropathy. Female patients are post menopause and smokers were excluded. All patients received furosemide, statin and MEA inhibitors or Angiotensin inhibitors, but no anti-oxidants. All participants presented DR at any stage, according to the International Clinical Diabetic Retinopathy guidelines, with HbA1C less than 7.5 g/dl. Spectrophotometric detection of MDA from serum was performed at baseline and after intake of 300 mg vitamin E daily for three months. Comparisons were performed using SPSS 20.0 statistical software. Significance was defined as p<0.05.
There was a statistically significant difference before and after the intake of vitamin E (p<0.0001, Wilcoxon matched-pairs signed-ranks test), which presented in all stages of DR. In proliferative DR stage, vitamin E had greater treatment effect in patients who were treated before with laser photocoagulation and intravitreal corticosteroids than in those treated with intravitreal anti-VEGF agents (-0.53±0.12 vs. -0.17±0.08, p<0.001, Mann-Whitney-Wilcoxon test), although the two groups did not differ significantly after the intake of vitamin E (p=0.240, Mann-Whitney-Wilcoxon test).
Our study suggests that vitamin E may have a positive effect on oxidative stress, even in patients with severe stages of DR.