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Retrospective comparison of spectralis and cirrus spectral domain optical coherence tomography in quantifying macular thickness in patients with centre involving diabetic macular edema

Poster Details

First Author: J.Kirk UK

Co Author(s):    K. Witts   I. Stratton   P. Scanlon   Q. Mohamed         0   0 0   0 0   0 0   0 0

Abstract Details


To compare central retinal thickness measurements obtained using two spectral domain high-resolution optical coherence tomography (SD-OCT) devices in patients with centre-involving diabetic macular oedema (CIDMO)


Gloucestershire Hospitals NHS foundation trust


36 eyes with centre involving diabetic macular oedema underwent dilated sequential imaging with Cirrus (Carl Zeiss Meditec) and Spectralis (Heidelberg Engineering) SD-OCT. The automated central retinal thickness (CRT) was compared between the two devices.


The Mean CRT was significantly higher with the Spectralis SD-OCT compared to the Cirrus SD-OCT (360 μm vs. 315 μm, p<0.001). Mean difference in CRT between devices was 24.47μm ± 21.03μm.


Spectralis OCT on average measures greater CRT compared to Cirrus HD-OCT in patients with CIDMO. This has major implications in implementation of NICE guidelines, which have recommended treatment only in patients with CRT above 400 microns, and has implications on re-treatment decisions when patients are assessed with different SD- OCT devices. Previous studies compared SD OCT devices in normal subjects, we found a much greater variability in patients with central macular oedema. Variation in algorithms and segmentation boundaries used by different SD OCT devices may explain the differences and greater variability in diseased eyes.

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