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Posters

Angioid streaks and pseudoxanthoma elasticum- a familial case report

Poster Details

First Author: M.Ingolotti ARGENTINA

Co Author(s):    M.N. Gabin   J. Ayerza   M. Iglicki   B.A. Schlaen   M. Saravia      0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

To report a familial case of angioid streaks with or without pseudoxantoma elasticum and evaluate the presence of choroidal neovasculatization.

Setting:

Retina Section of Hospital Universitario Austral

Methods:

This is a familial case report. A family of 10 members including a couple and 8 siblings were recruited. Collected data from patients included age, gender, best corrected visual acuity (BCVA), intraocular pressure, fundus examination, fluorescein angiography (FA) and Optical coherence tomography (OCT). They were all examined by a dermatologist in order to identify the presence of pseudoxanthoma elasticum and biopsy was performed if there was a positive case. Bevacizumab (AvastinĀ®) was the anti- VEGF therapy used in cases of neovascularization. Follow-up after treatment was done by BCVA, OCT and FA.

Results:

A total of 7 out of 10 patients had angioid streaks in the fundus exam. Two out of 7 also had pseudoxantoma ellasticum. One out of 7 had choroidal neovascularization which required monthly intravitreal injection of bavacizumab (AvastinĀ®) for at least 4 months. In this patient a 6 - month follow up had shown an improvement in BCVA from 20/50 pre injection to 20/20 after injection.

Conclusions:

The relationship of angioid streaks and pseudoxanthoma elasticum is well-described in the literature. Our report shows that the screening of the whole family group in mandatory when a single case is identified so that there is an early detection of any possible complications. This case is another example that the use of intravitreal bevacizumab for choroidal neovascularizaition in angioid streaks has favorable results that persist in the future although further studies should be made to more precisely determine the results of this therapy.

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