First Author: D.Güven TURKEY
Co Author(s): A. Mavi Yıldız R.S. Erol Y. Altuntaş 0 0 0 0 0 0 0 0 0
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To assess the association of systemic parameters and presence of macular edema in patients with NPDR especially considering vitamin D which has anti-inflammatory and anti-angiogenic properties.
Patients referred from Diabetes Clinic and having NPDR were recruited consecutively during summer time. They were grouped as macular edema(ME) negative (Group I) and ME positive(Group II)
There were 20 patients in each group and none of the patients were taking multivitamin supplement. In addition to detailed eye examination, optic coherence tomography and if needed flourescein angiography was applied. Serum Vitamin D, HbA1c, fasting blood glucose levels(FBG), body mass indices(BMI) and duration of diabetes were recorded.
Mean age was significantly higher in Group II being 64.34 whereas 56.60 in Group I.(p<0.05) Mean BMI was significantly higher in Group I being 33.36 whereas 30.1 in Group II. Mean HbA1c(%) was 8.81 in Group I and 8.55 in Group II. No significant difference was found between the groups with respect to duration of diabetes, levels of vitamin D, HbA1c, FBG and sex distribution. Mean vitamin D levels were 19.56±10.56 ng/ml and 14.16±9.18 ng/ml in Group I and II respectively.(p=0.092) Levels of vitamin D and HbA1c presented an average inverse relation considering all patients. In Group I, Vitamin D and HbA1c levels showed stronger inverse correlation whereas in Group II, Vitamin D and HbA1c levels do not show any correlation.
Previous studies showed lower vitamin D levels in diabetic patients when compared with normal controls. In this preliminary study although not significant we found a trend of lower vitamin D levels in NPDR patients with macular edema. Average inverse relation between vitamin D and HbA1c in NPDR patients needs to be evaluated since diabetic control and serum vitamin D values may have an influence on each other.