First Author: F.Ghassemi IRAN
Co Author(s): 0 0 0 0 0 0 0 0 0
Back to previous
To evaluate cytomegalovirus and herpes virus DNA in aqueous humor and serum of patients with Coats disease by polymerase chain reaction (PCR) with hypercoagulability state.
Hospital based cross sectional retrospective study.
After definite diagnosis of Coats disease in those patients needed to intravitreal injection or surgery under sterile conditions 0.2mL of aqueous humor of patients was aspirated and the concomitant serum evaluation for CMV polymerase chain reaction was performed. We also evaluated blood specimen by serum proteins electrophoresis, lipid profile, protein C and S level, and anti-Herpes simplex I/II, anti-CMV. The control group included those patients with congenital cataract without any other vascular defect and congenital infections causing the cataract and some patients with senile cataract.
Cytomegalovirus DNA (PCR) was not found in any of patient and control groups. All the specimens of aqueous humor and serum were negative for CMV. The level of LDL, CRP, PLT, Hb, aqueous Gama Globulin, serum alpha1Globulin, serum and alpha 2 Globulin in serum electrophoresis were significantly higher in patient group comparing with the control group. The protein S abnormality and higher serum level of anti herpes simplex virus in Coats patients was an important finding in this study.
Higher serum concentration of anti HSV antibody and it association with some other hypercoagulability factors is a significant finding in this study that larger studies for evaluating this findings is a necessity.