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Posters

Vitreal levels of pro- and anti-inflammatory cytokines in patients with idiopathic epiretinal membrane and macular hole

Poster Details

First Author: N.Celik GERMANY

Co Author(s):    J. Kopitz   G.U. Auffarth   S. Dithmar            0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

Cytokines play a role in the pathogenesis of several vitreoretinal disorders. In our study we compared vitreous levels of pro- and anti-inflammatory cytokines in patients with idiopathic epiretinal membrane (iERM) and macular hole (MH) compared to a control group.

Setting:

Department of Ophthalmology and department of Pathology, University of Heidelberg

Methods:

Twenty-one patients underwent vitrectomy due to iERM (n=11) or MH (n=10). Vitreous samples from keratoplasty donor eyes (n=9) without anamnestic or macroscopic ocular pathologies were taken within 48 hours post mortem and served as control. Mean age was 68.1 ± 12.1 years (11 males, 19 females). Samples were immediately stored at -80°C. Levels of the cytokines IL-1a, IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, INF-gamma, TNF-alpha, GM-CSF and VEGF were determined via multiplex protein array (Luminex Inc., Austin, USA).

Results:

In the groups of iERM and MH values of IL-6 (66.1 ± 14.4 pg/ml und 62.4 ± 8.4 pg/ml vs. 39.0 ± 85.02 pg/ml), IL-10 (16.0 ± 4.5 pg/ml und 13.8 ± 2.8 pg/ml vs. 5.4 ± 8.1 pg/ml), IL-12 (23.7 ± 7.6 pg/ml und 19.0 ± 7.1 pg/ml vs. 21.5 ± 50.7 pg/ml), INF-gamma (20.9 ± 9.1 pg/ml und 17.9 ± 5.3 pg/ml vs. 0.9 ± 2.7 pg/ml), TNF-alpha (34.3 ± 15.0 pg/ml und 35.2 ± 10.8 pg/ml vs. 1.7 ± 3.4 pg/ml) and VEGF (40.3 ± 24.1 pg/ml und 32.4 ± 15.9 pg/ml vs. 8.2 ± 11.2 pg/ml) were significantly higher than in the control group (p<0.01). In iERM IL-4 was significantly elevated compared with control group (1.0 ± 2.1 pg/ml vs. 5.8 ± 4.4 pg/ml, p<0.01). IL-1b was significantly increased in MH patients in contrast to the control group (27.4 ± 16.8 pg/ml vs. 18.1 ± 35.2 pg/ml, p<0.05).

Conclusions:

Compared to the control group iERM and MH showed statistically significant increased levels for pro- and anti-inflammatory cytokines. In comparison of the two diseases similar cytokine levels were obtained. Further research concerning the selective regulation of cytokines may help to understand disease pathogenesis.

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