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Choroidal changes in relation to levels of hemoglobin A1c and duration of disease in diabetic macular edema

Poster Details

First Author: F.J.Ascaso SPAIN

Co Author(s):    K. Zabadani   L. Herrera   C. Caramello   C. Almenara   N. Cruz   J.A. Cristóbal   0   0 0   0 0   0 0   0 0

Abstract Details


We investigate changes in subfoveal choroidal thickness in eyes with diabetic macular edema according to levels of hemoglobin A1c and duration of disease using enhanced depth imaging optical coherence tomography (EDI-OCT).


Department of Ophthalmology, “Lozano Blesa” University Clinic Hospital, Zaragoza, Spain.


57 eyes corresponding to 47 type-2 diabetes patients (mean age 68.3 ± 9.8 49-90 years) who presented with diabetic macular edema were prospectively imaged using EDI-OCT on Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT. The mean subfoveal choroidal thickness was 221.8 ± 91.9 µm (range, 104-584). The mean level of hemoglobin A1c was 7.5 ± 1.9 mg/dl (range, 5.2-13.4), the measurement of hemoglobin A1c was made over the past two to three months of the study. The mean time of duration of diabetes was 15.5 ± 8.3 years (range, 4-38).


Choroidal thickness measurements at subfoveal area were weakly correlated with serum levels of hemoglobin A1c (r = 0.117, p=0.388). We found a statistically significant negative correlation between duration of disease and subfoveal choroidal thickness (r = -0.304 p= 0.021).


Subfoveal choroidal thickness does not seem to be related to serum levels of hemoglobin A1c. The subfoveal choroidal thickness is negatively correlated with the time course of diabetes mellitus.

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