First Author: K.Mousavi SPAIN
Co Author(s): M. Rodriguez J. Gallardo M. Barbany J. Casado S. Moreno 0 0 0 0 0 0 0 0 0
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Serpiginous Choroiditis is a progressive, recurrent and chronic, inflammatory disease of choriocapillaris that secondarily involves retina. The disease often involves macula causing severe sight loss. The purpose of this case report is to assess the effects of Infliximab in the treatment of refractory Serpiginous Choroiditis
Terrassa, Barcelona, Spain
We report a case of refractory serpiginous choroiditis under conventional treatment. A 53 year-old male from Barcelona was referred with a 4 week history of blurred vision in his left eye that was getting progressively worse. His past ocular history was significant for idiopathic macular corioretinitis in the right eye 4 years earlier. Best corrected visual acuity was 0.3 in the right eye and 0.9 in the left eye. Serpiginous Choroiditis was diagnosed after tuberculosis and other systemic infections were ruled out. Systemic workup included complete autoimmune analysis, serologic tests, complete blood cell count and biochemistry with ACE. All tests were within normal ranges. Despite the treatment with systemic and intraocular corticosteroids combined with cyclosporine A and azathioprine, the disease progressed. The macula was threatened. The only treatment that proved to be effective in inducing remission during two years follow up was infliximab. This patient previously received antituberculous chemotherapy. After a one year treatment with Infliximab, the patient had a new relapse in his left eye when we reduced the dose of Infliximab.
In Conclusion, this case report supports that the use of Infliximab in refractory Serpiginous Choroiditis could be the alternative therapy being extremely cautious with tuberculosis. We recommend that these patients previously receive antituberculous chemotherapy