First Author: J.Montero-Moreno SPAIN
Co Author(s): A.A. Merino-Iglesias S. Perez-Martin C. González Urueña 0 0 0 0 0 0 0 0 0
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To report factors affecting changes in intraocular pressure (IOP) after intravitreal injection of bevacizumab (IVI) in patients with choroidal neovascularization
Single centre, prospective, non randomized interventional study
Patients with subfoveal and juxtafoveal choroidal neovascularization secondary to age related macular degeneration and high myopia were treated by an IVI of 0.05 mL bevacizumab. Applanation IOP (Goldmann tonometry) was determined immediately before and after the injection as well as 10, 20 and 30 minutes after the injection. Anterior and posterior segment slit-lamp examination was performed prior to and after the injection, and axial length was determined.
Fifty-nine eyes (34 right, 25 left) from 59 patients (30 female, 29 male) were evaluated. Mean age at the moment of the IVI was 73±12 years, and the average number of previous IVI was 10.6±11.3. Basal IOP was 16.9±4.1 mmHg, 41.5±10.1 immediately after the injection, 26.0±7.2 mmHg 10 minutes after the injection, 21.3±5.7 mmHg 20 minutes after the injection and 19.2±5.2 mmHg 30 minutes after the injection. The phakic status and the integrity of the posterior lens capsule were not associated with differences in IOP rise after the IVI. A longer axial length and a lower number of previous IVI were associated with milder changes in IOP (p=0.02 to 0.04, and p=0.003 to p<0.0001, respectively), and higher baseline IOP was associated with larger increases of postinjection IOP (p=0.01 to p<0.0001; Student t test for unpaired data).
Post IVI changes in IOP seem to be associated with the previous number of IVI, axial length and baseline IOP.