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A single-centre study of ocriplasmin in a homogenous group of patients with vitreomacular traction

Poster Details

First Author: P.Szurman GERMANY

Co Author(s):    S. Kazerounian   M. Waizel   K.T. Boden            0   0 0   0 0   0 0   0 0

Abstract Details


Ocriplasmin (JETREA®; Alcon) has been available in Germany for the treatment of patients with vitreomacular traction (VMT), including when associated with a macular hole ≤400 µm, since May 2013. This study was designed to evaluate ocriplasmin treatment in a homogenous group of patients with VMT, classified according to the International Vitreomacular Traction Study (IVTS) Group criteria.


Patients with optical coherence tomography (OCT)-confirmed VMT, who were treated with ocriplasmin between July 2013 and January 2014 (inclusive), at the Knappschaft Eye Clinic, Sulzbach, Germany.


A total of 24 eyes of 23 patients with visually significant VMT were treated with a single intravitreal injection of ocriplasmin 125 µg. Diagnosis was made with spectral domain OCT (SD-OCT). The patients were assigned to subgroups with either focal or broad vitreomacular adhesion (VMA), according to the IVTS Group classification. The primary study endpoint was posterior vitreomacular detachment 4 weeks after injection; secondary endpoints were best-corrected visual acuity (BCVA), macular thickness and morphology after injection.


There were 23 patients (24 eyes) who completed the 1-month follow-up visit. At this timepoint, 10 out of 24 eyes showed a resolution of the VMT on SD-OCT (success rate 41.7%). Successfully treated eyes showed a mean reduction in macular thickness from 372 µm to 360 µm (p=0.19). The same eyes showed a mean (±standard deviation) BCVA improvement from logMAR 0.25 (±0.60) to logMAR 0.21 (±0.62) 1 month after injection. Subgroup analysis showed no significant difference between eyes with broad or focal VMA.


This is the first study to evaluate intravitreal ocriplasmin treatment in a homogenous group of patients with VMT alone. Our results show that ocriplasmin treatment resolves VMT in 41.7% of eyes. In these eyes, a slight improvement in visual acuity was observed 1 month after injection. Subgroup analysis showed no difference in the type of adhesion as classified by the IVTS Group.

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