First Author: T.Empeslidis UK
Co Author(s): V. Konidaris K. Tsaousis P. Kumar 0 0 0 0 0 0 0 0 0
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To present 4 cases of patients suffering from punctuate inner chorioretinopathy PIC and multifocal chorioretinopathy and panuveitis. We report 18 months follow up and provide evidence of the effectiveness of Dexamethasone 0.7mg intravitreal implant in non infectious uveitis.
The patients were diagnosed monitored and treated at the Leicester Royal Infirmary. The study is a retrospective case series.
Four female patients mean age 44.5 years 5 eyes 3 suffering from PIC and one patient suffered from MFC and panuveitis. Treatment with Dexamethasone 0.7mg intravitreal implant was given to all patients. Two eyes developed choroidal neovascular membrane CNVM and treated additionally with intravitreal Bevacizumab 1.25mg in 0.05ml injections. The patients were followed up from 18 to 6 months.
The three eyes that did not develop CNVM managed to preserve visual acuity same as on baseline 6/6, 6/9, 6/9 with the disease in remission for up to 18 months. When CNVM complicated the outcome was poor with VA 6/60 and CF in the affected eyes.
The use of Dexamethasone 0.7mg in non infectious uveitis and more so in PIC and MFC and panuveitis provides encouraging results with preserved vision and no symptoms of the disease for 18 months in one eye. When we have CNVM complicated with the primary disease the outcome is poor. Further studies with a higher number of patients and possibly a randomised controlled trial is needed to further evaluate the efficacy of Dexamethasone 0.7mg intravitreal implant as an alternative treatment in non infectious uveitis.