First Author: E.Chan SINGAPORE
Co Author(s): L. Shen G. Sundar C. Chee 0 0 0 0 0 0 0 0 0
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No recent epidemiologic data is available for retinoblastoma in Asians. This study aims to evaluate long-term trends in retinoblastoma incidence by demographic factors in Singapore from 1968 to 2012.
Population-based registry data. The Singapore Cancer Registry database was evaluated for retinoblastoma incidence rates by gender, ethnicity, and year of diagnosis for four consecutive 10-year time intervals: 1968 to 1978, 1979 to 1989, 1990 to 2000, and 2001 to 2012.
The Singapore Cancer Registry database was evaluated for retinoblastoma incidence rates by gender, ethnicity, and year of diagnosis for four consecutive 10-year time intervals: 1968 to 1978, 1979 to 1989, 1990 to 2000, and 2001 to 2012. Percent change in incidence and incidence rate ratios (IRR) were evaluated.
There were 119 children aged <21 years with retinoblastoma. Overall retinoblastoma incidence increased 44.8% from 1968 to 1978, but remained stable from 1979 to 2012. There was a slight female predominance from 1968 to 1978 (IRR 1.45) and recently from 2000 to 2012 (IRR 1.36), but a slight male predominance from 1978 to 1979 (IRR 0.92) and from 1989 to 1999 (IRR 0.63). This was due to a 58.8% increase in female incidence and 25.7% decrease in male incidence from 2000 to 2012. Over all four time periods, retinoblastoma incidence was uniformly higher in Malay than Chinese children (range of IRR: 1.20 to 2.21). The incidence was stable in Chinese (range: 5.1 to 9.9 per 1,000,000 persons) and Malays (range: 11.4 to 15.0 per 1,000,000 persons), but showed greater fluctuation in Indians (range: 0 to 38.9 per 1,000,000 persons).
Over the last 30 years, retinoblastoma incidence in Singapore has remained stable. Gender and racial factors may have an effect on retinoblastoma risk in this population.