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Posters

Retinoblastoma incidence trends in Singapore from 1968 to 2012- data from the Singapore cancer registry

Poster Details

First Author: E.Chan SINGAPORE

Co Author(s):    L. Shen   G. Sundar   C. Chee            0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

No recent epidemiologic data is available for retinoblastoma in Asians. This study aims to evaluate long-term trends in retinoblastoma incidence by demographic factors in Singapore from 1968 to 2012.

Setting:

Population-based registry data. The Singapore Cancer Registry database was evaluated for retinoblastoma incidence rates by gender, ethnicity, and year of diagnosis for four consecutive 10-year time intervals: 1968 to 1978, 1979 to 1989, 1990 to 2000, and 2001 to 2012.

Methods:

The Singapore Cancer Registry database was evaluated for retinoblastoma incidence rates by gender, ethnicity, and year of diagnosis for four consecutive 10-year time intervals: 1968 to 1978, 1979 to 1989, 1990 to 2000, and 2001 to 2012. Percent change in incidence and incidence rate ratios (IRR) were evaluated.

Results:

There were 119 children aged <21 years with retinoblastoma. Overall retinoblastoma incidence increased 44.8% from 1968 to 1978, but remained stable from 1979 to 2012. There was a slight female predominance from 1968 to 1978 (IRR 1.45) and recently from 2000 to 2012 (IRR 1.36), but a slight male predominance from 1978 to 1979 (IRR 0.92) and from 1989 to 1999 (IRR 0.63). This was due to a 58.8% increase in female incidence and 25.7% decrease in male incidence from 2000 to 2012. Over all four time periods, retinoblastoma incidence was uniformly higher in Malay than Chinese children (range of IRR: 1.20 to 2.21). The incidence was stable in Chinese (range: 5.1 to 9.9 per 1,000,000 persons) and Malays (range: 11.4 to 15.0 per 1,000,000 persons), but showed greater fluctuation in Indians (range: 0 to 38.9 per 1,000,000 persons).

Conclusions:

Over the last 30 years, retinoblastoma incidence in Singapore has remained stable. Gender and racial factors may have an effect on retinoblastoma risk in this population.

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