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Tomographic analysis of retinal nerve fiber and ganglion cell layers in chronic heavy smokers

Poster Details

First Author: Y.Totan TURKEY

Co Author(s):    M.S. Dervişoğulları   E. Güler   A. Yüce            0   0 0   0 0   0 0   0 0

Abstract Details


To evaluate the retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCI-IPL) thicknesses in chronic heavy smokers using spectral domain optical coherence tomography (SD OCT).


Turgut Özal University Medical Faculty Department of Ophthalmology


20 subjects (16 male and 4 female) who were chronic heavy smokers more than 10 years at least 20 cigarettes per a day and 22 healthy, age and gender matched non-smoker subjects (18 men and 4 women) were included in this study. Quantitative analysis of the GC-IPL and peripapillary RNFL was performed by Cirrus HD-OCT (Carl Zeiss Meditec).


The mean age of the smokers and controls were 39.8 ± 8.4 years and 38.6 ± 10.4 years, respectively. Age, sex, AL, SE and IOP values were not statistically significant between smokers and controls (p< 0.05). The mean GC-IPL thickness was not statistically significant between the smokers (84.3 ± 5.8 µm) and controls (86.1 ± 8.0 µm) (p> 0.05). Additionally, subgroups analyses of GP-ICL did not reach statistical significance between the groups The mean RNFL thickness was significantly thinner in smokers (92.3 ± 3.5 µm) compared to the controls (97.6 ± 8.2 µm) (p= 0.03). The mean RNFL thickness in each quadrant was also significantly thinner in smokers (p< 0.05) except for the temporal quadrant (p= 0.96).


In chronic heavy smokers, decreased RNFL thickness may be a parameter confirming the involvement of smoking as a risk factor for glaucoma and optic neuropathies.

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