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Choroidal neovascularitazion secondary to choroideremia

Poster Details

First Author: J.Torres-Peña SPAIN

Co Author(s):    J. Campos-Pavón                  0   0 0   0 0   0 0   0 0

Abstract Details


To report a rare complication of Choroideremia


University Hospital 12 de Octubre, Department of Ophthalmology, Complutense University of Madrid, Madrid, Spain


30 years old male refers nyctalopia, reduced peripheral vision and decreased visual acuity (VA) in both eyes (BE), more intense in the left eye (LE) of 20/100, in the fundus shows areas of atrophy the retinal pigment epithelium (RPE), retina and choroid, alternating with areas of RPE hypertrophy in BA and LE supports macular hemorrhage with choroidal neovascularization (CNV) that was confirmed by fluorescein angiography (FA) and the Optical coherence tomography (OCT). Definitive diagnosis was obtained by genetic studies, which detected hemizygosity a deletion in exons 6 and 7 in the REP1 gene coding sequence. Treatment is not performed because the patient did not come to the following reviews


At 6 months the patient returns. At this time presents a AV en LE of 20/25. OCT confirms the disappearance of subretinal fluid suggesting spontaneous resolution of CNV.


There are very few reports in the literature of neovascular membranes in the context of this disease, which have been described mainly in the early or intermediate stages. It is believed that this is due to the limited capacity of the membrane to grow to be surrounded by atrophy of the RPE and choroid, so perhaps it is advisable to wait in some cases spontaneous resolution. But today would be indicated treatment antiangiogenics especially to avoid fibrosis secondary to exudation.

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