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The natural progression of Pattern dystrophy on autofluorescence

Poster Details

First Author: K.Spiteri Cornish UK

Co Author(s):    P.Y.S. Chua   V. McBain               0   0 0   0 0   0 0   0 0

Abstract Details


The aim of our study is to show the natural progression of the different types of Pattern Dystrophy (PD) on autofluorescence.


Retinal Imaging and Electrophysiology Service in Aberdeen University Hospital.


Retrospective review of all images (autofluoresence [AF], infra-red [IRR] and near-infrared reflectance [NIR]) of all patients with a confirmed diagnosis of PD, with particular emphasis on patients with a minimum of 4 years follow-up from diagnosis. Natural history of the condition was assessed in the change in area of hypo- and hyper-fluorescence on AF, and complemented by OCT (optical coherence tomography) where available. Patients were classified into the different subtypes of PD.


39 patients with PD were assessed. Evidence of progression of the disease is very clear on serial imaging with the increase deposition of lipofuscin material (increase in the size and number of hyper-autofluorescent foci) which is subsequently replaced by hypo-autofluorescence (atrophy). This is true of all subtypes of PD. Higher number of cases are required for linear regression analysis and estimation of progression rates.


Our study clearly depicts the progression of pattern dystrophy over time, with increase deposition of lipofuscin and lipofuscin-like material in the subretinal space, followed by photoreceptor and RPE atrophy and associated visual loss. Further studies are required in this area to attempt to correlate rate of progression with different subtypes or genotypes of the disease.

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