First Author: V.P.Loo MALAYSIA
Co Author(s): Y.H. Yew V. Subrayan 0 0 0 0 0 0 0 0 0
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This study was to examine the choroidal thickness in patients with diabetes mellitus using enhanced depth imaging mode of spectral domain optical coherence tomography(EDI-OCT).
The subjects were recruited from the Eye Clinic of University Malaya Medical Center, Kuala Lumpur.
Fifty-two patients (52 eyes) with diabetes and 24 normal subjects were recruited for high-definition raster scanning of the macula choroid with the Enhanced Depth Imaging mode of Cirrus HD-OCT to assess for the choroidal thickness and its relationship with age, axial length, body mass index(BMI), duration of diabetes and HbA1c. The quality of the EDI-OCT scan was also analysed. Diabetics were futher subdivided into 4 groups: 1) no diabetic retinopathy, 2) non-proliferative diabetic retinopathy, 3) diabetic macula oedema and 4) proliferative diabetic retinopathy. Choroidal thickness were measured at 21 predetermined points in the macula at 500µm interval starting from the fovea extending to all 4 quadrants.
Reliable measurements from 2 independent observers were analysed. The choroidal thickness did not differ significantly in all the 21 points between controls and diabetics, including all the subgroups. There was a significant negative linear relationship between the foveal choroidal thickness and foveal retinal thickness in the NPDR group (r=-0.755, p-value = 0.005) but not in the other groups. Mean choroidal thickness correlated negatively with age and axial length, though the significance varied. Ordered logistic regression analysis found that OCT signal strength had no effect on the quality of the choroidal image.
There was no difference in the choroidal thickness between diabetics and controls, regardless of their diabetic retinopathy stages.