First Author: I.Flores-Moreno SPAIN
Co Author(s): J. Ruiz-Medrano P. Peña-García J.A. Montero L. Arias-Barquet J.M. Ruiz-Moreno 0 0 0 0 0 0 0 0 0
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To determine retinal thickness (RT) profile in a population without ocular disease using swept-source optical coherence tomography (SS-OCT) and to correlate it with the corresponding choroidal thickness (CT).
Castilla-La Mancha University. Spain
Cross-sectional, non-interventional study. 217 eyes from 128 patients with no known ocular disease, with spherical equivalent (SE) between ± 3D, were imaged using a prototype SS-OCT system (Topcon Corporation, Japan). A horizontal RT profile of the macula was automatically created from the internal limiting membrane to the upper boundary of retinal pigment epithelium (RPE) at the center of the foveal. Three further determinations were performed every 1000μm nasal to the fovea and five more temporal to the fovea. Choroidal measurements were manually determined at the same positions from the posterior edge of RPE to the choroid/sclera junction by two observers independently. The subjects were divided into five groups according to age.
The mean age was 33.3±24.4 years old (range from 4 to 95). Mean SE was 0.02±1.40 D (from -3.00 to +3.00). Mean foveal RT was 192.63±23.81 μm (from 101 to 335) and mean macular RT was 251.79±13.09μm (from 200.89 to 284.22). Mean subfoveal CT was 303.9±84.3μm (from 107.0 to 539.5) and macular CT was 260.2±68.5μm (from 114.4 to 455.2). A statistically significant difference in mean macular RT was found between men and women (p<0.001; Student t test). Simple regression analysis showed a negative correlation between mean macular RT and age (r=-0.348; p<0.001; Spearman test). No correlations were found between RT and CT (p=0.84; Pearson test).
Using SS OCT, the retina was determined to be thinner in women. In addition, age tended to result in retinal thinning. The retinal thickness profile revealed that the temporal retina is thinner than the nasal retina due to the differential nerve fiber layer thickness.