First Author: B.Erden TURKEY
Co Author(s): S. Bölükbaşı Ö. Kuru M. Elçioğlu 0 0 0 0 0 0 0 0 0
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Comparison of central macular thickness(CMT), macular volume( MV) and retinal nerve fiber layer (RNFL) findings of multiple sclerosis(MS) patients with the healthy (H) population.
Okmeydanı Education & Research Hospital/ Istanbul
38 eyes of 19 MS patients and 46 eyes of 23 healhty voluntary people were enrolled into this prospective study. The mean duration of MS diagnosis was 71 months and 14 of 38 eyes had a history of optic neuritis. Best corrected visual acuity ( BCVA ), intraocular pressure (IOP) and demograpic findings were recorded. In both groups, CMT,MV, mean RNFL were measured with Zeiss Cirrus SD-OCT in both groups. Data were analysed with PAWS statistics software.
There was no statistically significant difference in mean age ( 33 vs 39) and sex between MS and H groups . Mean BCVA was significantly better in H group ( 0,87 vs 0,98; p<0,05). Mean CMT was 239 µ in MS, 242 µ in H group, MV was found as 11,9 in MS and 10,1 in H group, both were statistically insignificant. Mean RNFL was significantly higher ( 92 vs 83 ) in H group. Regarding RNFL values in 4 quadrants, while in superior quadrant there was no difference found ( 105 vs 108 ), in temporal ( 57 vs 65 ) and nasal ( 62 vs 70 ) quadrants RNFL was signicantly thinner in MS group. In inferior quadrant the RNFL of MS group (108 )was significantly ( p<0,005 ) thinner than the H group (123).No significant CMT ( 230 vs 244 ) and mean RNFL ( 84 vs 83 ) difference was found in both MS subgroups with and without history of optic neuritis.
In MS patients mean RNFL was found thinner compared to the healthy population in all quadrants, mostly in the inferior area. No difference was observed in central foveal OCT parameters. The history of optic neuritis does not contribute to the thinning of RNFL in MS patients.