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Evolution of hiperreflective foci on RVO-associated macular edema after an intravitreal dexamethasone implant injection

Poster Details

First Author: F.J.Ascaso SPAIN

Co Author(s):    C. Almenara   L. Lavilla   K. Zabadani   L. Herrera   I. Pinilla   J.A. Cristóbal   0   0 0   0 0   0 0   0 0

Abstract Details


To investigate the relationship between the presence of macular hyperreflective dots (HRD) detected by spectral-domain optical coherence tomography (SD-OCT) and visual outcomes in eyes with macular edema secondary to retinal vein occlusion (RVO), following treatment with intravitreal dexamethasone implant (Ozurdex®).


Department of Ophthalmology, University Clinic Hospital, Zaragoza, Spain.


Retrospective observational study of 16 consecutive cases of RVO-associated macular edema: five central retinal vein occlusion (CRVO) and 11 branch retinal vein occlusion (BRVO) treated with Ozurdex®. The correlation between best corrected visual acuity (BCVA) (logMAR), central macular thickness (CMT) and the presence of HRD in SD-OCT before the treatment and two months postoperatively was determined.


CMT decreased significantly after treatment (553±131 μm vs 300±67 μm, p <0.0001). Although there was a visual acuity improvement in seven of the 16 eyes (43.7%), there were no significant differences in BCVA between before and following treatment (0.61±0.28 vs 0,59±0.31, p> 0.05). Numerous HRD were detected in 11 eyes (68.8%), disappearing in eight of them (72.7%) after corticosteroid intravitreal therapy. Two months following treatment, logMAR BCVA was significantly worse in the eyes with numerous HRD (0.90±0.17) than in those with few or absent HRD (0.52 ±0.29) (p = 0.045, independent Student t test).


Disappearance of HRD following intravitreal dexamethasone therapy and the consequent improvement in visual function would support the hypothesis that hiperreflective foci could represent inflammatory cells. Nevertheless, the presence of HRD in SD-OCT in patients with macular edema resulting from RVO was not able to predict BCVA after intravitreal Ozurdex®.

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