First Author: N.Kanchanaranya THAILAND
Co Author(s): D. Rojdamrongratana P. Piyasoonthorn 0 0 0 0 0 0 0 0 0
Back to previous
To report the incidence rate, clinical features, managements, and presumed risk factors of acute post-intravitreal anti-VEGF drug injection endophthalmitis secondary to therapeutic intravitreal ranibizumab and bevacizumab injections.
A retrospective review of all consecutive eyes after intravitreal injections was performed at the Thammasat University Hospital, Pathumthani, from June 2008 to September 2013.
Data collected at diagnosis included patient demographics, intravitreal injection details, pre- and post-injection management, visual acuity, clinical features and managements, causative organisms, and clinical outcomes.
During the 5 years study interval, 1,169 intravitreal injections were performed. The overall incidence rate of endophthalmitis was 0.0017 % (2 of 1169 injections). In our series, the endophthalmitis occurred after the 1st and 2ndinjection. Bacterial cultures and gram stain revealed coagulase-negative Staphylococcus species (n=1) and no organism found (n=1). All cases were treated efficient in limiting the devastating sequels by intravitreal antibiotics, steroids and pars plana vitrectomy. The visual acuity recovers useful vision in one case and devastating of vision in another case.
Acute endophthalmitis is a rare potential complication after intravitreal injection. Prognosis of endophthalmitis varies widely depending upon the severity of the infection, the organism involved and the amount of damage the eye sustains from inflammation and scarring. Further studies are required to clarify the best prophylactic techniques to prevent this rare complication.