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Posters

Mixed (Q3M 12m + PRN 12m) versus pro re nata (PRN 24m) dosing regime- 24 month visual outcomes of ranibizumab treatment for wet age related macular degeneration (wAMD)

Poster Details

First Author: L.L.Tan UK

Co Author(s):    M. Johnson   D. Knight   P. Johnstone            0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

The PRN regime consists of 3 loading injections followed by injections given if patients achieve the PRN criteria of loss of 5 letters or more, fresh haemorrhage or increase fluid on ocular coherence tomography scan. The Mixed regime was introduced in 2010 to improve visual acuity (VA) outcome. This Mixed regime consists of 3 loading injections followed by injections every three months for 1 year. After the first year, patients are given injections only if they achieve the PRN criteria. This study aims to determine the VA outcome for the two regimes over a 24 months period.

Setting:

Single-centre study at a teaching hospital

Methods:

Retrospective data analysis on the VA outcomes of Ranibizumab injection for wAMD were compared between the two regimes. The mean baseline best corrected VA (BCVA), mean letters gained, percentage of patients who gained ≥ 15 letters, percentage of patients who lost < 15 letters and the mean number of injections at 24 months were audited.

Results:

A total of 81 patients were followed up for 24 months in the Mixed regime whilst 30 patients were followed up in the PRN 24m regime. The baseline BCVA was comparable at 56 letters in the Mixed regime and 55 letters in the PRN regime. The mean letters gained were higher with the Mixed regime at 4.7 letters compared to -3.3 letters with the PRN regime. The percentage of patients who gained ≥ 15 letters were higher in the Mixed regime at 24% compared to 20% with the PRN regime. Similarly, the percentage of patients who lost < 15 letters were higher in the Mixed regime at 90% compared to 80% with the PRN regime. The mean number of injections was similar at 8.8 injections for the Mixed regime and 9 injections for the PRN regime. However, the Mixed regime has higher mean number of injections given in the first year at 6.3 compared to 4.9 in PRN regime.

Conclusions:

The Mixed regime has better VA outcomes compared to the PRN regime. The high number of injections given in the first year of the Mixed regime maintained the good VA outcomes in the second year even though regular injections were not given.

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