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Time-domain OCT and spectral domain OCT in neovascular age-related macular degeneration

Poster Details

First Author: A.Ozkaya TURKEY

Co Author(s):    Z. Alkin   Y. Karakucuk   A.T. Yazici   A. Demirok         0   0 0   0 0   0 0   0 0

Abstract Details


To evaluate the ability of spectral-domain optical coherence tomography to detect subtle amounts of retinal fluid when the choroidal neovascularization is detected as inactive via time-domain optical coherence tomography and clinical examination in patients with neovascular age-related macular degeneration (nAMD).


Beyoglu Eye Training and Research Hospital


Forty-nine eyes of 49 patients with nAMD after ranibizumab treatment were included in this cross-sectional, prospective study. All patients were imaged with TD-OCT and SD-OCT at the same visit one month after a ranibizumab injection. The presence of subretinal, intraretinal, and subretinal pigment epithelium fluid (subRPE) in SD-OCT was evaluated; also mean central retinal thickness and the rate of vitreoretinal surface disorders detected via the two devices were evaluated.


The mean CRT of the patients via TD-OCT and SD-OCT was 218.1±51.3 microns (range 139-418 microns), and 325.7±78.8 (range 222-508 microns). The mean ratio between the mean CRT measured with SD-OCT and TD-OCT was 1.51 ± 0.09. Sixteen patients (32.6%) showed subretinal, intraretinal, or subRPE fluid via SD-OCT. In detail; 8 patients showed (%16.3) subretinal fluid, 10 patients (%20.4) showed intraretinal fluid, and 3 patients (%6.1) showed SubRPE fluid. The ability of detecting vitreoretinal surface disorders was comparable between the two devices, except vitreomacular traction.


SD-OCT is essential for the nAMD patients who are on an as-needed treatment regimen with ranibizumab. Only TD-OCT and clinical examination may cause insufficient treatment in this group of patients.

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