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Posters

Exudative age-related macular degeneration-continuation of anti-VEGF treatment based on disease activity

Poster Details

First Author: A.Liaska GREECE

Co Author(s):    T. Pallantzas   E. Makri   V. Dimopoulou   S. Stamelou   K. Andrianopoulou      0   0 0   0 0   0 0   0 0

Abstract Details



Purpose:

in patients with neovascular(age-related) macular degeneration(n-AMD)on anti-vascular-endothelial-growth-factor(anti-VEGF) treatment, disease activity may last for years. Criteria as total number of injections or duration of treatment as used to stop reimbursement of anti-VE GF treatment are not related to disease activity while the prerequisite of visual acuity better or equal to 1/10 may exclude from treatment patients who still have the potential of visual improvement. In the present study we examine the clinical course of eyes with n-AMD after visual acuity drops below 1/10 or/and duration of treatment over 3 years in comparison to the fellow eye suffering from end-stage disease(macular scar).

Setting:

Department of Ophthalmology, General Hospital of Lamia, Lamia, GREECE

Methods:

retrospective, case series. 5 patients (3 men, 2 women) age 82-90 years, with active n-AMD in one eye and macular scar (end-stage n-AMD) in the fellow eye (natural course of the disease) continued the anti-VEGF treatment in relation to disease activity after visual acuity dropped below 1/10 and/or beyond 3 years of anti-VEGF treatment , until the disease became inactive for at least 3 months. Aparametric methods were used to compare the results in both eyes. All patients were addressed the question which eye they considered as “seeing”.

Results:

the final visual acuity in the treated eyes was 1/40-2/10 while in the fellow eyes was Hand Movement to Counting Fingers (1 m) (p=0.0422, Wilcoxon signed rank sum test). The size of the lesion was 1-2 disc diameters in the treated eyes while in the fellow eyes occupied the whole area between the temporal vascular arcades (p=0.0253, Wilcoxon signed rank sum test). In questionnaire all patients described as “seeing” the treated eye.

Conclusions:

continuation of anti-VEGF treatment in eyes with low vision and active disease may preserve useful vision and thus possibly contributing in quality of life of patients with neovascular age-related macular degeneration.

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